HitPredict

Interactor 1: HS74L (O95757)
Heat shock 70 kDa protein 4L (Heat shock 70-related protein APG-1) (Heat shock protein family H member 3) (Heat-shock protein family A member 4-like protein) (HSPA4-like protein) (Osmotic stress protein 94)
Gene: HSPA4L

Interactor 2: INSR (P06213)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 839 Hs			1 1382
+	Hs
		411458 HS105_HUMAN (1-839): 0: 925: 58.24		INSR_HUMAN (1-1382): 0: 1530: 100.00
+	Hs
		320797 HS74L_HUMAN (1-839): 0: 1032: 100.00		IGF1R_HUMAN (31-1380): 0: 1353: 56.11
+	Hs
		320817 HS74L_HUMAN (1-839): 0: 1032: 100.00		EPHA8_HUMAN (644-1322): 3.66e-168: 531: 20.68
+	Hs
		320798 HS74L_HUMAN (1-839): 0: 1032: 100.00		ROS1_HUMAN (511-1377): 3.38e-158: 530: 22.63
+	Hs
		435511 HSP7C_HUMAN (563-695): 1.3e-27: 121: 17.91		IGF1R_HUMAN (31-1380): 0: 1353: 56.11
+	Hs
		1072565 HS105_HUMAN (1-839): 0: 925: 58.24		EPHA7_HUMAN (562-1356): 4.76e-172: 541: 19.48
+	Hs
		665505 HS105_HUMAN (1-839): 0: 925: 58.24		EPHA8_HUMAN (644-1322): 3.66e-168: 531: 20.68
+	Hs
		320789 HS74L_HUMAN (1-839): 0: 1032: 100.00		ERBB2_HUMAN (978-1381): 5.36e-93: 330: 25.67
+	Hs
		320928 HS74L_HUMAN (1-839): 0: 1032: 100.00		ALK_HUMAN (982-1339): 1.96e-70: 263: 40.53
+	Hs
		320790 HS74L_HUMAN (1-839): 0: 1032: 100.00		NTRK1_HUMAN (996-1286): 9.16e-68: 247: 42.62
+	Hs
		320862 HS74L_HUMAN (1-839): 0: 1032: 100.00		NTRK3_HUMAN (996-1290): 1.93e-64: 238: 39.43
+	Hs
		320811 HS74L_HUMAN (1-839): 0: 1032: 100.00		FGFR3_HUMAN (1015-1287): 2.21e-62: 231: 40.78
+	Hs
		383646 HSP74_HUMAN (1-839): 0: 931: 62.60		ERBB2_HUMAN (978-1381): 5.36e-93: 330: 25.67
+	Hs
		1267783 HS105_HUMAN (1-839): 0: 925: 58.24		ALK_HUMAN (982-1339): 1.96e-70: 263: 40.53
+	Hs
		384373 HSP74_HUMAN (1-839): 0: 931: 62.60		NTRK1_HUMAN (996-1286): 9.16e-68: 247: 42.62
+	Hs
		385266 HS105_HUMAN (1-839): 0: 925: 58.24		NTRK1_HUMAN (996-1286): 9.16e-68: 247: 42.62
+	Hs
		1081553 HS105_HUMAN (1-839): 0: 925: 58.24		NTRK3_HUMAN (996-1290): 1.93e-64: 238: 39.43
+	Hs
		609191 HSP74_HUMAN (1-839): 0: 931: 62.60		FGFR3_HUMAN (1015-1287): 2.21e-62: 231: 40.78
+	Hs
		384163 HSP7C_HUMAN (563-695): 1.3e-27: 121: 17.91		NTRK1_HUMAN (996-1286): 9.16e-68: 247: 42.62
+	Hs
		384372 HS71L_HUMAN (563-703): 9.9e-28: 121: 19.72		NTRK1_HUMAN (996-1286): 9.16e-68: 247: 42.62