HitPredict

Interactor 1: HS74L (O95757)
Heat shock 70 kDa protein 4L (Heat shock 70-related protein APG-1) (Heat shock protein family H member 3) (Heat-shock protein family A member 4-like protein) (HSPA4-like protein) (Osmotic stress protein 94)
Gene: HSPA4L

Interactor 2: DNJB1 (P25685)
DnaJ homolog subfamily B member 1 (DnaJ protein homolog 1) (Heat shock 40 kDa protein 1) (HSP40) (Heat shock protein 40) (Human DnaJ protein 1) (hDj-1)
Gene: DNAJB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	DnaJ~HSP70
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006986 - response to unfolded protein
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 839 Hs			1 340
+	Hs
		636257 HSP74_HUMAN (1-839): 0: 931: 62.60		DNJB1_HUMAN (1-340): 5.05e-137: 394: 100.00
+	Hs
		636386 HS105_HUMAN (1-839): 0: 925: 58.24		DNJB1_HUMAN (1-340): 5.05e-137: 394: 100.00
+	Hs
		714449 HSP74_HUMAN (1-839): 0: 931: 62.60		DNJB4_HUMAN (1-339): 1.15e-134: 388: 64.60
+	Hs
		1267773 HS105_HUMAN (1-839): 0: 925: 58.24		DNJB4_HUMAN (1-339): 1.15e-134: 388: 64.60
+	Hs
		1123860 HS105_HUMAN (1-839): 0: 925: 58.24		Q59E89_HUMAN (1-339): 2.98e-132: 382: 64.31
+	Hs
		279281 HSP74_HUMAN (1-839): 0: 931: 62.60		DNJB5_HUMAN (1-339): 3.31e-126: 366: 59.71
+	Hs
		279330 HS105_HUMAN (1-839): 0: 925: 58.24		DNJB5_HUMAN (1-339): 3.31e-126: 366: 59.71
+	Hs
		681540 HS105_HUMAN (1-839): 0: 925: 58.24		DNJA1_HUMAN (5-339): 2.97e-117: 346: 32.77
+	Dm
		1096122 Q9VUC1_DROME (1-837): 0: 855: 42.71		DNAJ1_DROME (1-339): 2.7e-118: 346: 51.32
+	Ce
		450534 HSP1_CAEEL (2-603): 0: 808: 28.78		Q20774_CAEEL (1-334): 7.16e-117: 342: 51.80
+	Sc
		633056 HSP79_YEAST (5-709): 3.76e-134: 417: 35.05		MAS5_YEAST (5-339): 5.57e-109: 325: 31.29
+	Sc
		627839 HSP79_YEAST (5-709): 3.76e-134: 417: 35.05		SIS1_YEAST (6-336): 1.7e-47: 165: 34.63
+	Hs
		636256 HS71L_HUMAN (563-703): 9.9e-28: 121: 19.72		DNJB1_HUMAN (1-340): 5.05e-137: 394: 100.00
+	Hs
		714088 HS71L_HUMAN (563-703): 9.9e-28: 121: 19.72		DNJB4_HUMAN (1-339): 1.15e-134: 388: 64.60
+	Hs
		279272 HSP7C_HUMAN (563-695): 1.3e-27: 121: 17.91		DNJB5_HUMAN (1-339): 3.31e-126: 366: 59.71
+	Hs
		279280 HS71L_HUMAN (563-703): 9.9e-28: 121: 19.72		DNJB5_HUMAN (1-339): 3.31e-126: 366: 59.71
+	Hs
		681341 HS71L_HUMAN (563-703): 9.9e-28: 121: 19.72		DNJA1_HUMAN (5-339): 2.97e-117: 346: 32.77
+	Hs
		243275 HSP7C_HUMAN (563-695): 1.3e-27: 121: 17.91		DNJA2_HUMAN (2-339): 2.35e-115: 341: 33.24
+	Hs
		243312 HS71L_HUMAN (563-703): 9.9e-28: 121: 19.72		DNJA2_HUMAN (2-339): 2.35e-115: 341: 33.24
+	Hs
		714087 HS71L_HUMAN (563-703): 9.9e-28: 121: 19.72		DJB11_HUMAN (2-338): 8.5e-105: 313: 32.26