HitPredict

Interactor 1: IL33 (O95760)
Interleukin-33 (IL-33) (Interleukin-1 family member 11) (IL-1F11) (Nuclear factor from high endothelial venules) (NF-HEV) [Cleaved into: Interleukin-33 (95-270); Interleukin-33 (99-270); Interleukin-33 (109-270)]
Gene: IL33

Interactor 2: ILRL1 (Q01638)
Interleukin-1 receptor-like 1 (EC 3.2.2.6) (Protein ST2)
Gene: IL1RL1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.86 0.60 0.721

The method score is based on:

Property Details
Experiments 19559631, 19439663, 19836339, 23980170, 16286016
Identification Methods pull down, molecular sieving, nuclear magnetic resonance, surface plasmon resonance, x-ray crystallography
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0002826 - negative regulation of T-helper 1 type immune response
GO:0005576 - extracellular region
GO:0030225 - macrophage differentiation
GO:0032689 - negative regulation of type II interferon production
GO:0032722 - positive regulation of chemokine production
and 4 others

more...
Homologous interactions 2

Homologous interactions

Color coding for hit scores

1 270
Hs

1 556
+ Mm
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024