HitPredict

Interactor 1: LSM8 (O95777)
U6 snRNA-associated Sm-like protein LSm8
Gene: LSM8

Interactor 2: RSMN (P63162)
Small nuclear ribonucleoprotein-associated protein N (snRNP-N) (Sm protein D) (Sm-D) (Sm protein N) (Sm-N) (SmN) (Tissue-specific-splicing protein)
Gene: SNRPN

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	LSM~LSM
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0046540 - U4/U6 x U5 tri-snRNP complex
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 96 Hs			1 240
+	Hs
		321370 LSM8_HUMAN (1-96): 2.62e-34: 114: 100.00		RSMB_HUMAN (1-168): 1.09e-43: 148: 96.43
+	Hs
		539178 LSM7_HUMAN (4-85): 9.47e-28: 98.4: 30.23		RSMB_HUMAN (1-168): 1.09e-43: 148: 96.43
+	Hs
		167663 LSM1_HUMAN (2-91): 1.79e-25: 93.8: 33.33		RSMB_HUMAN (1-168): 1.09e-43: 148: 96.43
+	Hs
		538899 RSMN_HUMAN (2-82): 9.84e-24: 91.8: 27.59		RSMB_HUMAN (1-168): 1.09e-43: 148: 96.43
+	Hs
		538826 RSMB_HUMAN (2-82): 1.56e-23: 91.5: 27.59		RSMB_HUMAN (1-168): 1.09e-43: 148: 96.43
+	Hs
		538891 RUXG_HUMAN (3-75): 1.69e-23: 86.8: 24.66		RSMB_HUMAN (1-168): 1.09e-43: 148: 96.43
+	Hs
		68400 RUXGL_HUMAN (3-75): 1.81e-21: 81.8: 24.66		RSMB_HUMAN (1-168): 1.09e-43: 148: 96.43
+	Hs
		912026 RUXG_HUMAN (3-75): 1.69e-23: 86.8: 24.66		RSMN_HUMAN (1-212): 4.46e-39: 137: 100.00
+	Hs
		68412 RUXGL_HUMAN (3-75): 1.81e-21: 81.8: 24.66		RSMN_HUMAN (1-212): 4.46e-39: 137: 100.00
+	Sc
		766934 LSM7_YEAST (4-77): 4.18e-21: 81.8: 24.69		RSMB_YEAST (1-165): 2.64e-36: 128: 28.72
+	Sc
		766937 LSM3_YEAST (5-83): 9.83e-21: 80.3: 24.39		RSMB_YEAST (1-165): 2.64e-36: 128: 28.72
+	Sc
		766917 LSM8_YEAST (1-91): 2.98e-20: 79.5: 27.47		RSMB_YEAST (1-165): 2.64e-36: 128: 28.72
+	Sc
		766911 RUXG_YEAST (2-75): 1.4e-19: 76.8: 24.00		RSMB_YEAST (1-165): 2.64e-36: 128: 28.72
+	Hs
		123841 RSMB_HUMAN (2-82): 1.56e-23: 91.5: 27.59		SPT5H_HUMAN (100-228): 4.97e-25: 105: 17.69
+	Dm
		984916 RSMB_DROME (3-70): 8.97e-23: 88.4: 29.73		Q8IPZ7_DROME (8-94): 7.25e-26: 99.3: 26.44
+	Hs
		297811 RSMB_HUMAN (2-82): 1.56e-23: 91.5: 27.59		K0754_HUMAN (49-240): 8.86e-22: 95.8: 14.04