HitPredict - High confidence protein-protein interactions

Interactor 1: RIGI (O95786)
Antiviral innate immune response receptor RIG-I (ATP-dependent RNA helicase DDX58) (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (RNA sensor RIG-I) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I)
Gene: RIGI

Interactor 2: RIGI (O95786)
Antiviral innate immune response receptor RIG-I (ATP-dependent RNA helicase DDX58) (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (RNA sensor RIG-I) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I)
Gene: RIGI

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.974

Property	Details
Experiments	29563291, 32612200, 37005687, 23264040, 18948594, 21102435, 25259935, 17190814, 20581823, 24590070
Identification Methods	pull down, affinity chromatography technology, comigration in non denaturing gel electrophoresis, anti tag coimmunoprecipitation, x-ray crystallography, comigration in gel electrophoresis
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	CARD_2~CARD_2, CARD_2~RIG-I_C, DEAD~DEAD, DEAD~Helicase_C, DEAD~RIG-I_C, DEAD~RIG-I_C-RD, Helicase_C~Helicase_C, Helicase_C~RIG-I_C, Helicase_C~RIG-I_C-RD, RIG-I_C~RIG-I_C, RIG-I_C~RIG-I_C-RD, RIG-I_C-RD~RIG-I_C-RD
Common GO terms	GO:0002230 - positive regulation of defense response to virus by host GO:0002735 - positive regulation of myeloid dendritic cell cytokine production GO:0002753 - cytoplasmic pattern recognition receptor signaling pathway GO:0003690 - double-stranded DNA binding GO:0003724 - RNA helicase activity and 34 others more... GO:0003725 - double-stranded RNA binding GO:0003727 - single-stranded RNA binding GO:0005524 - ATP binding GO:0005525 - GTP binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005923 - bicellular tight junction GO:0008270 - zinc ion binding GO:0009597 - detection of virus GO:0009615 - response to virus GO:0010467 - gene expression GO:0010628 - positive regulation of gene expression GO:0015629 - actin cytoskeleton GO:0016887 - ATP hydrolysis activity GO:0030334 - regulation of cell migration GO:0031625 - ubiquitin protein ligase binding GO:0032587 - ruffle membrane GO:0032725 - positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032727 - positive regulation of interferon-alpha production GO:0032728 - positive regulation of interferon-beta production GO:0032755 - positive regulation of interleukin-6 production GO:0032757 - positive regulation of interleukin-8 production GO:0032760 - positive regulation of tumor necrosis factor production GO:0034344 - regulation of type III interferon production GO:0038187 - pattern recognition receptor activity GO:0039529 - RIG-I signaling pathway GO:0043330 - response to exogenous dsRNA GO:0045087 - innate immune response GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0051607 - defense response to virus GO:0060760 - positive regulation of response to cytokine stimulus GO:0071360 - cellular response to exogenous dsRNA GO:0140374 - antiviral innate immune response GO:1990904 - ribonucleoprotein complex
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1	925
Hs

1	925

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Last updated: 15 Jul 2024