HitPredict

Interactor 1: RIGI (O95786)
Antiviral innate immune response receptor RIG-I (ATP-dependent RNA helicase DDX58) (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (RNA sensor RIG-I) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I)
Gene: RIGI

Interactor 2: UBB (P0CG47)
Polyubiquitin-B [Cleaved into: Ubiquitin]
Gene: UBB

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	24622840
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CARD_2~ubiquitin
Common GO terms	GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 925 Hs			1 229
+	Hs
		321868 RIGI_HUMAN (1-925): 0: 635: 100.00		UBC_HUMAN (1-153): 4.05e-53: 183: 99.35
+	Hs
		171470 RIGI_HUMAN (1-925): 0: 635: 100.00		UBD_HUMAN (79-228): 1.03e-29: 110: 31.41
+	Hs
		321864 RIGI_HUMAN (1-925): 0: 635: 100.00		ISG15_HUMAN (3-154): 1.46e-26: 102: 32.26
+	Hs
		398085 IFIH1_HUMAN (6-922): 1.74e-132: 425: 28.46		ISG15_HUMAN (3-154): 1.46e-26: 102: 32.26
+	Mm
		476804 DDX46_MOUSE (61-872): 1.8e-85: 297: 11.95		UBC_MOUSE (1-181): 6.49e-62: 207: 96.13
+	Hs
		475678 CHD3_HUMAN (50-807): 3.51e-88: 311: 11.41		UBC_HUMAN (1-153): 4.05e-53: 183: 99.35
+	Hs
		923970 CHD3_HUMAN (50-807): 3.51e-88: 311: 11.41		RS27A_HUMAN (153-228): 1.76e-44: 147: 100.00
+	At
		952785 DCL4_ARATH (223-845): 1.2e-61: 231: 19.84		UBQ3_ARATH (1-153): 2.79e-55: 180: 95.43
+	Hs
		476139 DDX17_HUMAN (410-831): 1.46e-49: 189: 11.75		UBC_HUMAN (1-153): 4.05e-53: 183: 99.35
+	Hs
		133967 DDX3X_HUMAN (411-774): 1.03e-44: 174: 13.92		RS27A_HUMAN (153-228): 1.76e-44: 147: 100.00
+	Hs
		398056 DDX17_HUMAN (410-831): 1.46e-49: 189: 11.75		ISG15_HUMAN (3-154): 1.46e-26: 102: 32.26
+	Mm
		93326 ASCC3_MOUSE (258-412): 1.17e-12: 74.5: 24.39		UBC_MOUSE (1-181): 6.49e-62: 207: 96.13
+	Hs
		133836 DDX3X_HUMAN (411-774): 1.03e-44: 174: 13.92		ISG15_HUMAN (3-154): 1.46e-26: 102: 32.26
+	Hs
		398024 DDX42_HUMAN (455-774): 2.26e-43: 172: 15.00		ISG15_HUMAN (3-154): 1.46e-26: 102: 32.26
+	At
		1091701 RH15_ARATH (194-618): 3.73e-18: 89.9: 12.59		UBQ3_ARATH (1-153): 2.79e-55: 180: 95.43
+	Hs
		476041 ASCC3_HUMAN (258-412): 1e-12: 74.9: 23.78		UBC_HUMAN (1-153): 4.05e-53: 183: 99.35
+	At
		98670 F4K203_ARATH (258-412): 1.96e-13: 77.2: 22.09		UBQ3_ARATH (1-153): 2.79e-55: 180: 95.43
+	Hs
		398032 ASCC3_HUMAN (258-412): 1e-12: 74.9: 23.78		ISG15_HUMAN (3-154): 1.46e-26: 102: 32.26