HitPredict

Interactor 1: RIGI (O95786)
Antiviral innate immune response receptor RIG-I (ATP-dependent RNA helicase DDX58) (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (RNA sensor RIG-I) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I)
Gene: RIGI

Interactor 2: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	28287082
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 925 Hs			1 906
+	Mm
		610612 RIGI_MOUSE (1-924): 0: 616: 77.08		CBL_MOUSE (1-906): 0: 888: 91.59
+	Hs
		610467 DDX17_HUMAN (410-831): 1.46e-49: 189: 11.75		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		571308 DDX5_HUMAN (459-798): 1.16e-47: 182: 14.05		CBL_HUMAN (1-906): 0: 917: 100.00
+	Mm
		610605 DDX3X_MOUSE (411-774): 2.43e-44: 172: 13.92		CBL_MOUSE (1-906): 0: 888: 91.59
+	Mm
		1163120 RIGI_MOUSE (1-924): 0: 616: 77.08		KMT2C_MOUSE (426-905): 5.2e-11: 69.2: 11.26
+	Hs
		181717 DDX3Y_HUMAN (380-774): 3.83e-45: 175: 13.70		CRBG2_HUMAN (456-876): 1.43e-12: 74.1: 16.49
+	Sc
		624087 DBP2_YEAST (459-773): 1.02e-46: 177: 12.72		SEC31_YEAST (554-901): 1.04e-09: 64.6: 8.27
+	Hs
		757612 IF4A3_HUMAN (238-609): 6.59e-19: 92.3: 13.17		MDC1_HUMAN (450-878): 1.89e-11: 70.3: 9.33