HitPredict

Interactor 1: RIGI (O95786)
Antiviral innate immune response receptor RIG-I (ATP-dependent RNA helicase DDX58) (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (RNA sensor RIG-I) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I)
Gene: RIGI

Interactor 2: TRI25 (Q14258)
E3 ubiquitin/ISG15 ligase TRIM25 (EC 6.3.2.n3) (Estrogen-responsive finger protein) (RING finger protein 147) (RING-type E3 ubiquitin transferase) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM25) (Tripartite motif-containing protein 25) (Ubiquitin/ISG15-conjugating enzyme TRIM25) (Zinc finger protein 147)
Gene: TRIM25

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.993

The method score is based on:

Property Details
Experiments 25172487, 19675569, 23264040, 19484123, 29357390, 30342007, 31600868, 34452305, 34313226, 34471099, 33024073, 17392790, 20406818, 21292167, 27122586, 28148787, 28594325, 30193849, 29563291, 30902577 and 15 others

more...
Identification Methods enzymatic study, pull down, affinity chromatography technology, anti tag coimmunoprecipitation, bimolecular fluorescence complementation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Helicase_C~SPRY
Common GO terms GO:0002753 - cytoplasmic pattern recognition receptor signaling pathway
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0045087 - innate immune response
GO:0140374 - antiviral innate immune response
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 925
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Last updated: 15 Jul 2024