HitPredict

Interactor 1: RIGI (O95786)
Antiviral innate immune response receptor RIG-I (ATP-dependent RNA helicase DDX58) (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (RNA sensor RIG-I) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I)
Gene: RIGI

Interactor 2: MAVS (Q7Z434)
Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA)
Gene: MAVS

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 1.00 0.996

The method score is based on:

Property Details
Experiments 20554965, 26061460, 28594325, 29263274, 30193849, 30267576, 30558248, 31433974, 32612200, 33649232, 34544279, 35075101, 36755358, 20071582, 19454348, 20406818, 21903422, 21292167, 22114345, 16177806 and 32 others

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Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, pull down, fluorescent resonance energy transfer, bimolecular fluorescence complementation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains CARD_2~CARD_2, CARD_2~RIG-I_C
Common GO terms GO:0002230 - positive regulation of defense response to virus by host
GO:0002735 - positive regulation of myeloid dendritic cell cytokine production
GO:0002753 - cytoplasmic pattern recognition receptor signaling pathway
GO:0032727 - positive regulation of interferon-alpha production
GO:0032728 - positive regulation of interferon-beta production
and 9 others

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Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 925
Hs

1 540
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Last updated: 15 Jul 2024