HitPredict

Interactor 1: RIGI (O95786)
Antiviral innate immune response receptor RIG-I (ATP-dependent RNA helicase DDX58) (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (RNA sensor RIG-I) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I)
Gene: RIGI

Interactor 2: RN135 (Q8IUD6)
E3 ubiquitin-protein ligase RNF135 (EC 2.3.2.27) (RIG-I E3 ubiquitin ligase) (REUL) (RING finger protein 135) (RING finger protein leading to RIG-I activation) (Riplet) (RING-type E3 ubiquitin transferase RNF135)
Gene: RNF135

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.94 1.00 0.973

The method score is based on:

Property Details
Experiments 19017631, 33373584, 35089988, 23950712, 19484123, 31006531, 33536170
Identification Methods affinity chromatography technology, two hybrid, pull down, enzymatic study, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Helicase_C~SPRY
Common GO terms GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0032728 - positive regulation of interferon-beta production
GO:0039529 - RIG-I signaling pathway
GO:0045087 - innate immune response
and 2 others

more...
Homologous interactions 17

Homologous interactions

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024