HitPredict

Interactor 1: RIGI (O95786)
Antiviral innate immune response receptor RIG-I (ATP-dependent RNA helicase DDX58) (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (RNA sensor RIG-I) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I)
Gene: RIGI

Interactor 2: DHX58 (Q96C10)
ATP-dependent RNA helicase DHX58 (EC 3.6.4.13) (ATP-dependent helicase LGP2) (Protein D11Lgp2 homolog) (RIG-I-like receptor 3) (RLR-3) (RIG-I-like receptor LGP2) (RLR)
Gene: DHX58

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.68 1.00 0.827

The method score is based on:

Property Details
Experiments 31237466, 17190814, 17020950
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains CARD_2~ResIII, CARD_2~RIG-I_C, DEAD~Helicase_C, DEAD~RIG-I_C, DEAD~RIG-I_C-RD, Helicase_C~Helicase_C, Helicase_C~ResIII, Helicase_C~RIG-I_C, Helicase_C~RIG-I_C-RD, RIG-I_C~ResIII, RIG-I_C~RIG-I_C, RIG-I_C~RIG-I_C-RD, RIG-I_C-RD~ResIII, RIG-I_C-RD~RIG-I_C-RD
Common GO terms GO:0002753 - cytoplasmic pattern recognition receptor signaling pathway
GO:0003724 - RNA helicase activity
GO:0003725 - double-stranded RNA binding
GO:0003727 - single-stranded RNA binding
GO:0005524 - ATP binding
and 5 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 925
Hs

1 678
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Last updated: 15 Jul 2024