HitPredict

Interactor 1: RIGI (O95786)
Antiviral innate immune response receptor RIG-I (ATP-dependent RNA helicase DDX58) (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (RNA sensor RIG-I) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I)
Gene: RIGI

Interactor 2: RN125 (Q96EQ8)
E3 ubiquitin-protein ligase RNF125 (EC 2.3.2.27) (RING finger protein 125) (T-cell RING activation protein 1) (TRAC-1)
Gene: RNF125

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	31827077, 17460044
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0008270 - zinc ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 925 Hs			1 232
+	Hs
		321931 RIGI_HUMAN (1-925): 0: 635: 100.00		TRIM7_HUMAN (9-228): 5.54e-39: 142: 13.58
+	Hs
		321932 RIGI_HUMAN (1-925): 0: 635: 100.00		TRIM6_HUMAN (24-228): 1.49e-36: 135: 16.43
+	Hs
		321891 RIGI_HUMAN (1-925): 0: 635: 100.00		TRAF3_HUMAN (5-175): 4.42e-33: 127: 19.89
+	Mm
		1163172 RIGI_MOUSE (1-924): 0: 616: 77.08		TRI11_MOUSE (22-166): 6.07e-26: 106: 18.37
+	Hs
		1290201 IFIH1_HUMAN (6-922): 1.74e-132: 425: 28.46		RN125_HUMAN (1-232): 1.03e-55: 179: 100.00
+	Hs
		1317601 IFIH1_HUMAN (6-922): 1.74e-132: 425: 28.46		TRIM7_HUMAN (9-228): 5.54e-39: 142: 13.58
+	Mm
		1246958 IFIH1_MOUSE (6-922): 5.22e-133: 426: 27.85		TRI13_MOUSE (28-228): 1.1e-34: 129: 15.17
+	Hs
		1318527 DICER_HUMAN (220-773): 2.88e-93: 326: 21.46		TRI31_HUMAN (22-226): 5.82e-36: 133: 12.50
+	Hs
		1024728 DHX58_HUMAN (242-920): 8.16e-96: 318: 30.59		TRAF3_HUMAN (5-175): 4.42e-33: 127: 19.89
+	Hs
		129586 DHX58_HUMAN (242-920): 8.16e-96: 318: 30.59		TRAF5_HUMAN (8-176): 3.95e-29: 116: 23.81
+	Hs
		1286224 DHX58_HUMAN (242-920): 8.16e-96: 318: 30.59		TRAF6_HUMAN (6-175): 2.58e-26: 108: 21.39
+	Hs
		536917 FANCM_HUMAN (206-922): 1e-72: 264: 17.69		TRI27_HUMAN (22-228): 7.77e-33: 125: 15.49
+	Hs
		134162 DDX3X_HUMAN (411-774): 1.03e-44: 174: 13.92		RN125_HUMAN (1-232): 1.03e-55: 179: 100.00
+	Hs
		1271648 DDX17_HUMAN (410-831): 1.46e-49: 189: 11.75		TRI31_HUMAN (22-226): 5.82e-36: 133: 12.50
+	Hs
		571586 DDX5_HUMAN (459-798): 1.16e-47: 182: 14.05		TRI31_HUMAN (22-226): 5.82e-36: 133: 12.50
+	Hs
		134198 DDX3X_HUMAN (411-774): 1.03e-44: 174: 13.92		TRI31_HUMAN (22-226): 5.82e-36: 133: 12.50
+	Hs
		134128 DDX3X_HUMAN (411-774): 1.03e-44: 174: 13.92		TRI58_HUMAN (22-231): 8.08e-34: 128: 15.95
+	Hs
		134011 DDX3X_HUMAN (411-774): 1.03e-44: 174: 13.92		TRAF3_HUMAN (5-175): 4.42e-33: 127: 19.89
+	Hs
		1271706 DDX17_HUMAN (410-831): 1.46e-49: 189: 11.75		TRAF6_HUMAN (6-175): 2.58e-26: 108: 21.39
+	Hs
		1252374 DDX17_HUMAN (410-831): 1.46e-49: 189: 11.75		LNX1_HUMAN (28-142): 7.17e-24: 101: 24.17