HitPredict

Interactor 1: M4K4 (O95819)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: MAP4K4

Interactor 2: RASN (P01111)
GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)
Gene: NRAS

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	30442766, 30194290
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0000165 - MAPK cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1239 Hs			1 189
+	Hs
		324711 M4K4_HUMAN (1-1239): 0: 1227: 100.00		RASK_HUMAN (16-189): 7.56e-85: 249: 85.71
+	Hs
		324808 M4K4_HUMAN (1-1239): 0: 1227: 100.00		RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71
+	Hs
		324710 M4K4_HUMAN (1-1239): 0: 1227: 100.00		RASH_HUMAN (1-188): 8.6e-78: 232: 85.64
+	Hs
		324774 M4K4_HUMAN (1-1239): 0: 1227: 100.00		RB11A_HUMAN (4-184): 1.5e-74: 224: 33.88
+	Hs
		350342 MINK1_HUMAN (1-1239): 0: 1120: 59.29		RASK_HUMAN (16-189): 7.56e-85: 249: 85.71
+	Hs
		1070297 MINK1_HUMAN (1-1239): 0: 1120: 59.29		RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71
+	Hs
		348783 MINK1_HUMAN (1-1239): 0: 1120: 59.29		RASN_HUMAN (1-189): 9.9e-80: 236: 100.00
+	Hs
		349478 MINK1_HUMAN (1-1239): 0: 1120: 59.29		RASH_HUMAN (1-188): 8.6e-78: 232: 85.64
+	Hs
		350664 TNIK_HUMAN (1-1239): 0: 1101: 60.56		RASK_HUMAN (16-189): 7.56e-85: 249: 85.71
+	Hs
		348995 TNIK_HUMAN (1-1239): 0: 1101: 60.56		RASN_HUMAN (1-189): 9.9e-80: 236: 100.00
+	Hs
		349719 TNIK_HUMAN (1-1239): 0: 1101: 60.56		RASH_HUMAN (1-188): 8.6e-78: 232: 85.64
+	Hs
		349893 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		RASK_HUMAN (16-189): 7.56e-85: 249: 85.71
+	Hs
		647896 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71
+	Hs
		348523 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		RASN_HUMAN (1-189): 9.9e-80: 236: 100.00
+	Hs
		349139 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		RASH_HUMAN (1-188): 8.6e-78: 232: 85.64
+	Hs
		348748 MARK2_HUMAN (8-669): 2.09e-122: 399: 14.10		RASN_HUMAN (1-189): 9.9e-80: 236: 100.00
+	Hs
		647864 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		RB11A_HUMAN (4-184): 1.5e-74: 224: 33.88
+	Hs
		148636 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		RAB1A_HUMAN (4-187): 1.35e-76: 229: 33.33
+	Hs
		647857 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		RAB2A_HUMAN (4-185): 1.53e-73: 222: 31.52
+	Hs
		149274 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		RAB1B_HUMAN (4-187): 1.35e-75: 226: 33.51