HitPredict

Interactor 1: M4K4 (O95819)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: MAP4K4

Interactor 2: RASH (P01112)
GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Ha-Ras) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed]
Gene: HRAS

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30442766
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0000165 - MAPK cascade GO:0005737 - cytoplasm GO:0030335 - positive regulation of cell migration GO:0043547 - positive regulation of GTPase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1239 Hs			1 189
+	Hs
		324709 M4K4_HUMAN (1-1239): 0: 1227: 100.00		RASN_HUMAN (1-188): 6.47e-88: 257: 85.64
+	Hs
		324711 M4K4_HUMAN (1-1239): 0: 1227: 100.00		RASK_HUMAN (1-188): 2.04e-84: 248: 86.24
+	Hs
		324774 M4K4_HUMAN (1-1239): 0: 1227: 100.00		RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90
+	Hs
		348783 MINK1_HUMAN (1-1239): 0: 1120: 59.29		RASN_HUMAN (1-188): 6.47e-88: 257: 85.64
+	Hs
		350342 MINK1_HUMAN (1-1239): 0: 1120: 59.29		RASK_HUMAN (1-188): 2.04e-84: 248: 86.24
+	Hs
		348995 TNIK_HUMAN (1-1239): 0: 1101: 60.56		RASN_HUMAN (1-188): 6.47e-88: 257: 85.64
+	Hs
		350664 TNIK_HUMAN (1-1239): 0: 1101: 60.56		RASK_HUMAN (1-188): 2.04e-84: 248: 86.24
+	Hs
		349478 MINK1_HUMAN (1-1239): 0: 1120: 59.29		RASH_HUMAN (16-189): 5.68e-73: 219: 100.00
+	Hs
		349719 TNIK_HUMAN (1-1239): 0: 1101: 60.56		RASH_HUMAN (16-189): 5.68e-73: 219: 100.00
+	Hs
		348523 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		RASN_HUMAN (1-188): 6.47e-88: 257: 85.64
+	Hs
		349893 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		RASK_HUMAN (1-188): 2.04e-84: 248: 86.24
+	Hs
		348748 MARK2_HUMAN (8-669): 2.09e-122: 399: 14.10		RASN_HUMAN (1-188): 6.47e-88: 257: 85.64
+	Hs
		350286 MARK2_HUMAN (8-669): 2.09e-122: 399: 14.10		RASK_HUMAN (1-188): 2.04e-84: 248: 86.24
+	Hs
		349916 AKT2_HUMAN (2-354): 7.38e-124: 393: 21.98		RASK_HUMAN (1-188): 2.04e-84: 248: 86.24
+	Hs
		647864 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90
+	Hs
		148636 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		RAB1A_HUMAN (4-186): 2.67e-75: 226: 31.28
+	Hs
		349139 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		RASH_HUMAN (16-189): 5.68e-73: 219: 100.00
+	Hs
		149274 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		RAB1B_HUMAN (4-186): 2.6e-74: 223: 31.44
+	Hs
		914159 MARK2_HUMAN (8-669): 2.09e-122: 399: 14.10		RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90
+	Hs
		349425 MARK2_HUMAN (8-669): 2.09e-122: 399: 14.10		RASH_HUMAN (16-189): 5.68e-73: 219: 100.00