HitPredict

Interactor 1: M4K4 (O95819)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: MAP4K4

Interactor 2: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.76	1.00	0.873

Property	Details
Experiments	30442766, 30639242, 30194290, 34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0000165 - MAPK cascade GO:0005737 - cytoplasm GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1239 Hs			1 189
+	Hs
		324710 M4K4_HUMAN (1-1239): 0: 1227: 100.00		RASH_HUMAN (1-188): 6.53e-87: 255: 86.77
+	Hs
		324709 M4K4_HUMAN (1-1239): 0: 1227: 100.00		RASN_HUMAN (1-189): 2.37e-85: 251: 85.19
+	Hs
		324808 M4K4_HUMAN (1-1239): 0: 1227: 100.00		RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28
+	Hs
		324774 M4K4_HUMAN (1-1239): 0: 1227: 100.00		RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88
+	Hs
		349478 MINK1_HUMAN (1-1239): 0: 1120: 59.29		RASH_HUMAN (1-188): 6.53e-87: 255: 86.77
+	Hs
		348783 MINK1_HUMAN (1-1239): 0: 1120: 59.29		RASN_HUMAN (1-189): 2.37e-85: 251: 85.19
+	Hs
		1070297 MINK1_HUMAN (1-1239): 0: 1120: 59.29		RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28
+	Hs
		349719 TNIK_HUMAN (1-1239): 0: 1101: 60.56		RASH_HUMAN (1-188): 6.53e-87: 255: 86.77
+	Hs
		348995 TNIK_HUMAN (1-1239): 0: 1101: 60.56		RASN_HUMAN (1-189): 2.37e-85: 251: 85.19
+	Hs
		350342 MINK1_HUMAN (1-1239): 0: 1120: 59.29		RASK_HUMAN (1-189): 8.4e-77: 229: 100.00
+	Hs
		350664 TNIK_HUMAN (1-1239): 0: 1101: 60.56		RASK_HUMAN (1-189): 8.4e-77: 229: 100.00
+	Hs
		349139 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		RASH_HUMAN (1-188): 6.53e-87: 255: 86.77
+	Hs
		348523 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		RASN_HUMAN (1-189): 2.37e-85: 251: 85.19
+	Hs
		647896 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28
+	Hs
		349893 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		RASK_HUMAN (1-189): 8.4e-77: 229: 100.00
+	Hs
		647857 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		RAB2A_HUMAN (4-183): 1.46e-75: 227: 32.97
+	Hs
		647864 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88
+	Hs
		148636 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		RAB1A_HUMAN (4-187): 7.4e-74: 222: 34.36
+	Hs
		149274 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		RAB1B_HUMAN (4-187): 1.21e-73: 221: 32.47
+	Hs
		148551 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		RAB13_HUMAN (4-186): 7.7e-72: 217: 36.76