HitPredict

Interactor 1: M4K4 (O95819)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: MAP4K4

Interactor 2: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0006468 - protein phosphorylation GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1239 Hs			1 509
+	Hs
		324719 M4K4_HUMAN (1-1239): 0: 1227: 100.00		LYN_HUMAN (1-509): 0: 582: 62.72
+	Hs
		411790 MINK1_HUMAN (1-1239): 0: 1120: 59.29		LCK_HUMAN (1-509): 0: 661: 100.00
+	Hs
		433891 MINK1_HUMAN (1-1239): 0: 1120: 59.29		LYN_HUMAN (1-509): 0: 582: 62.72
+	Hs
		434067 TNIK_HUMAN (1-1239): 0: 1101: 60.56		LYN_HUMAN (1-509): 0: 582: 62.72
+	Hs
		411606 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		LCK_HUMAN (1-509): 0: 661: 100.00
+	Hs
		411778 MARK2_HUMAN (8-669): 2.09e-122: 399: 14.10		LCK_HUMAN (1-509): 0: 661: 100.00
+	Hs
		433589 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		LYN_HUMAN (1-509): 0: 582: 62.72
+	Hs
		433949 MARK4_HUMAN (16-693): 2.51e-123: 400: 18.06		LYN_HUMAN (1-509): 0: 582: 62.72
+	Hs
		433850 MARK2_HUMAN (8-669): 2.09e-122: 399: 14.10		LYN_HUMAN (1-509): 0: 582: 62.72
+	Hs
		412167 AAPK1_HUMAN (8-555): 9.95e-123: 392: 16.85		FYN_HUMAN (30-507): 0: 586: 59.01
+	Hs
		433609 AKT2_HUMAN (2-354): 7.38e-124: 393: 21.98		LYN_HUMAN (1-509): 0: 582: 62.72
+	Hs
		412046 AKT1_HUMAN (2-354): 2.35e-122: 388: 20.82		FYN_HUMAN (30-507): 0: 586: 59.01
+	Hs
		522810 AKT1_HUMAN (2-354): 2.35e-122: 388: 20.82		SRC_HUMAN (20-507): 0: 586: 55.00
+	Mm
		403418 AKT1_MOUSE (2-354): 1.36e-122: 389: 20.82		SRC_MOUSE (28-507): 0: 583: 57.05
+	Hs
		412163 STK4_HUMAN (4-517): 8.55e-119: 379: 31.92		FYN_HUMAN (30-507): 0: 586: 59.01
+	Hs
		442897 M4K5_HUMAN (4-375): 4.65e-107: 359: 39.52		HCK_HUMAN (1-509): 0: 602: 65.04
+	Hs
		412425 M4K5_HUMAN (4-375): 4.65e-107: 359: 39.52		FYN_HUMAN (30-507): 0: 586: 59.01
+	Hs
		434099 M4K5_HUMAN (4-375): 4.65e-107: 359: 39.52		LYN_HUMAN (1-509): 0: 582: 62.72
+	Hs
		337455 STK4_HUMAN (4-517): 8.55e-119: 379: 31.92		ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21
+	Hs
		681838 AKT1_HUMAN (2-354): 2.35e-122: 388: 20.82		PTK6_HUMAN (63-499): 1.36e-161: 467: 40.41