HitPredict

Interactor 1: M4K4 (O95819)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: MAP4K4

Interactor 2: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22939624
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1239 Hs			1 732
+	Hs
		324721 M4K4_HUMAN (1-1239): 0: 1227: 100.00		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Hs
		432054 MINK1_HUMAN (1-1239): 0: 1120: 59.29		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		438348 MINK1_HUMAN (1-1239): 0: 1120: 59.29		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Hs
		432383 MAST1_HUMAN (3-947): 3.96e-126: 426: 14.68		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		432384 SIK3_HUMAN (7-915): 2.5e-127: 426: 15.13		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		148295 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		438640 MAST1_HUMAN (3-947): 3.96e-126: 426: 14.68		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Hs
		438641 SIK3_HUMAN (7-915): 2.5e-127: 426: 15.13		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Hs
		431573 AKT2_HUMAN (2-354): 7.38e-124: 393: 21.98		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		431800 AAPK1_HUMAN (8-555): 9.95e-123: 392: 16.85		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		431572 AKT1_HUMAN (2-354): 2.35e-122: 388: 20.82		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Rn
		812703 AKT1_RAT (2-354): 2.93e-122: 388: 20.82		HS90A_RAT (1-732): 0: 1085: 97.95
+	Mm
		432411 AKT1_MOUSE (2-354): 1.36e-122: 389: 20.82		HS90A_MOUSE (1-732): 0: 1083: 97.82
+	Hs
		148301 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Hs
		437928 AKT2_HUMAN (2-354): 7.38e-124: 393: 21.98		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Mm
		513660 AKT1_MOUSE (2-354): 1.36e-122: 389: 20.82		HS90B_MOUSE (19-732): 0: 1063: 86.98
+	Hs
		438123 AAPK1_HUMAN (8-555): 9.95e-123: 392: 16.85		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Bt
		964601 AKT1_BOVIN (2-354): 3.51e-123: 391: 20.82		HS90B_BOVIN (19-732): 0: 1059: 86.28
+	Sc
		365863 KCC4_YEAST (22-923): 2.08e-131: 430: 16.02		HSP82_YEAST (16-732): 0: 907: 60.08
+	Hs
		148349 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		ENPL_HUMAN (14-701): 0: 898: 46.78