HitPredict

Interactor 1: M4K4 (O95819)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: MAP4K4

Interactor 2: IGF1R (P08069)
Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
Gene: IGF1R

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~fn3, PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0030335 - positive regulation of cell migration GO:0043066 - negative regulation of apoptotic process GO:0046328 - regulation of JNK cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1239 Hs			1 1367
+	Hs
		324762 M4K4_HUMAN (1-1239): 0: 1227: 100.00		EPHA4_HUMAN (655-1342): 8.85e-179: 558: 23.12
+	Hs
		324809 M4K4_HUMAN (1-1239): 0: 1227: 100.00		EPHA7_HUMAN (656-1342): 1.15e-177: 555: 23.39
+	Hs
		324761 M4K4_HUMAN (1-1239): 0: 1227: 100.00		EPHA5_HUMAN (666-1275): 2.52e-173: 545: 24.01
+	Hs
		1072547 MINK1_HUMAN (1-1239): 0: 1120: 59.29		EPHA7_HUMAN (656-1342): 1.15e-177: 555: 23.39
+	Hs
		872460 MINK1_HUMAN (1-1239): 0: 1120: 59.29		EPHA5_HUMAN (666-1275): 2.52e-173: 545: 24.01
+	Hs
		1072625 TNIK_HUMAN (1-1239): 0: 1101: 60.56		EPHA7_HUMAN (656-1342): 1.15e-177: 555: 23.39
+	Hs
		872502 TNIK_HUMAN (1-1239): 0: 1101: 60.56		EPHA5_HUMAN (666-1275): 2.52e-173: 545: 24.01
+	Hs
		324713 M4K4_HUMAN (1-1239): 0: 1227: 100.00		NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61
+	Hs
		324728 M4K4_HUMAN (1-1239): 0: 1227: 100.00		FGFR1_HUMAN (972-1266): 1.32e-64: 238: 39.54
+	Hs
		324810 M4K4_HUMAN (1-1239): 0: 1227: 100.00		NTRK3_HUMAN (977-1262): 5.74e-64: 236: 39.16
+	Hs
		1083868 MINK1_HUMAN (1-1239): 0: 1120: 59.29		NTRK2_HUMAN (977-1256): 2.65e-70: 255: 43.95
+	Mm
		546291 TNIK_MOUSE (1-1239): 0: 1120: 62.43		NTRK2_MOUSE (977-1262): 3.02e-69: 252: 43.05
+	Hs
		508100 MINK1_HUMAN (1-1239): 0: 1120: 59.29		FGFR1_HUMAN (972-1266): 1.32e-64: 238: 39.54
+	Hs
		1081533 MINK1_HUMAN (1-1239): 0: 1120: 59.29		NTRK3_HUMAN (977-1262): 5.74e-64: 236: 39.16
+	Hs
		508260 TNIK_HUMAN (1-1239): 0: 1101: 60.56		FGFR1_HUMAN (972-1266): 1.32e-64: 238: 39.54
+	Hs
		1081641 TNIK_HUMAN (1-1239): 0: 1101: 60.56		NTRK3_HUMAN (977-1262): 5.74e-64: 236: 39.16
+	Hs
		324742 M4K4_HUMAN (1-1239): 0: 1227: 100.00		EPHB2_HUMAN (496-674): 6.85e-19: 95.5: 17.88
+	Hs
		665680 TNIK_HUMAN (1-1239): 0: 1101: 60.56		EPHB2_HUMAN (496-674): 6.85e-19: 95.5: 17.88
+	Hs
		384307 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61
+	Hs
		507867 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		FGFR1_HUMAN (972-1266): 1.32e-64: 238: 39.54