HitPredict

Interactor 1: M4K4 (O95819)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: MAP4K4

Interactor 2: PARP1 (P09874)
Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)]
Gene: PARP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.50	0.489

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1239 Hs			1 1014
+	Hs
		455113 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		PARP1_HUMAN (1-1014): 0: 1362: 100.00
+	Hs
		455589 MARK2_HUMAN (8-669): 2.09e-122: 399: 14.10		PARP1_HUMAN (1-1014): 0: 1362: 100.00
+	Hs
		455389 AAPK1_HUMAN (8-555): 9.95e-123: 392: 16.85		PARP1_HUMAN (1-1014): 0: 1362: 100.00
+	Hs
		455385 STK4_HUMAN (4-517): 8.55e-119: 379: 31.92		PARP1_HUMAN (1-1014): 0: 1362: 100.00
+	Hs
		324834 M4K4_HUMAN (1-1239): 0: 1227: 100.00		PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84
+	Hs
		310105 TNIK_HUMAN (1-1239): 0: 1101: 60.56		TNKS1_HUMAN (639-1012): 2.38e-74: 270: 18.53
+	Hs
		1188553 MINK1_HUMAN (1-1239): 0: 1120: 59.29		PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84
+	Hs
		1188737 NEK1_HUMAN (23-917): 5.54e-125: 418: 17.52		PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84
+	Hs
		647917 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84
+	Hs
		1025160 AAPK1_HUMAN (8-555): 9.95e-123: 392: 16.85		PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84
+	Hs
		681918 AKT1_HUMAN (2-354): 2.35e-122: 388: 20.82		PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84
+	Hs
		1027392 STK3_HUMAN (4-499): 3.17e-119: 381: 30.60		PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84
+	Hs
		1023071 STK4_HUMAN (4-517): 8.55e-119: 379: 31.92		PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84
+	Hs
		148542 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		DNLI3_HUMAN (3-104): 4.41e-30: 130: 25.46
+	Hs
		148986 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		ZCCHV_HUMAN (798-1005): 5.42e-21: 101: 15.71
+	Hs
		681917 AKT1_HUMAN (2-354): 2.35e-122: 388: 20.82		ZCCHV_HUMAN (798-1005): 5.42e-21: 101: 15.71
+	Hs
		1018168 M4K2_HUMAN (17-292): 1.97e-64: 237: 45.71		ZCCHV_HUMAN (798-1005): 5.42e-21: 101: 15.71