HitPredict

Interactor 1: M4K4 (O95819)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: MAP4K4

Interactor 2: CXA1 (P17302)
Gap junction alpha-1 protein (Connexin-43) (Cx43) (Gap junction 43 kDa heart protein)
Gene: GJA1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005925 - focal adhesion
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 1239 Hs			1 382
+	Hs
		567165 MINK1_HUMAN (1-1239): 0: 1120: 59.29		CXA1_HUMAN (1-382): 0: 545: 100.00
+	Hs
		567321 TNIK_HUMAN (1-1239): 0: 1101: 60.56		CXA1_HUMAN (1-382): 0: 545: 100.00
+	Hs
		1230271 MINK1_HUMAN (1-1239): 0: 1120: 59.29		CXD3_HUMAN (1-253): 8.84e-96: 289: 34.39
+	Hs
		566931 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		CXA1_HUMAN (1-382): 0: 545: 100.00
+	Hs
		567131 MARK2_HUMAN (8-669): 2.09e-122: 399: 14.10		CXA1_HUMAN (1-382): 0: 545: 100.00
+	Hs
		566939 AKT2_HUMAN (2-354): 7.38e-124: 393: 21.98		CXA1_HUMAN (1-382): 0: 545: 100.00
+	Hs
		566938 AKT1_HUMAN (2-354): 2.35e-122: 388: 20.82		CXA1_HUMAN (1-382): 0: 545: 100.00
+	Hs
		254446 ROCK2_HUMAN (15-536): 8.84e-107: 369: 22.02		CXA1_HUMAN (1-382): 0: 545: 100.00
+	Hs
		567345 M4K5_HUMAN (4-375): 4.65e-107: 359: 39.52		CXA1_HUMAN (1-382): 0: 545: 100.00
+	Hs
		647924 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		CXD3_HUMAN (1-253): 8.84e-96: 289: 34.39
+	Hs
		1183071 MARK2_HUMAN (8-669): 2.09e-122: 399: 14.10		CXD3_HUMAN (1-253): 8.84e-96: 289: 34.39