HitPredict

Interactor 1: M4K4 (O95819)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: MAP4K4

Interactor 2: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	36931259
Identification Methods	proximity labelling technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1239 Hs			1 248
+	Hs
		324772 M4K4_HUMAN (1-1239): 0: 1227: 100.00		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		684206 MINK1_HUMAN (1-1239): 0: 1120: 59.29		1433S_HUMAN (1-248): 3.48e-158: 440: 100.00
+	Hs
		684386 TNIK_HUMAN (1-1239): 0: 1101: 60.56		1433S_HUMAN (1-248): 3.48e-158: 440: 100.00
+	Hs
		909810 MINK1_HUMAN (1-1239): 0: 1120: 59.29		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		324769 M4K4_HUMAN (1-1239): 0: 1227: 100.00		1433G_HUMAN (1-242): 1.86e-98: 289: 65.16
+	Hs
		324794 M4K4_HUMAN (1-1239): 0: 1227: 100.00		1433F_HUMAN (2-242): 2.78e-96: 283: 64.20
+	Hs
		927301 MINK1_HUMAN (1-1239): 0: 1120: 59.29		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Hs
		647104 MINK1_HUMAN (1-1239): 0: 1120: 59.29		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		683539 MINK1_HUMAN (1-1239): 0: 1120: 59.29		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		904851 MINK1_HUMAN (1-1239): 0: 1120: 59.29		1433G_HUMAN (1-242): 1.86e-98: 289: 65.16
+	Hs
		982271 MINK1_HUMAN (1-1239): 0: 1120: 59.29		1433F_HUMAN (2-242): 2.78e-96: 283: 64.20
+	Hs
		684115 MRCKG_HUMAN (13-974): 7.6e-138: 459: 17.29		1433S_HUMAN (1-248): 3.48e-158: 440: 100.00
+	Hs
		927164 MRCKG_HUMAN (13-974): 7.6e-138: 459: 17.29		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Hs
		910182 MAST1_HUMAN (3-947): 3.96e-126: 426: 14.68		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		927679 MAST1_HUMAN (3-947): 3.96e-126: 426: 14.68		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Hs
		982137 MRCKG_HUMAN (13-974): 7.6e-138: 459: 17.29		1433F_HUMAN (2-242): 2.78e-96: 283: 64.20
+	Hs
		647402 SIK3_HUMAN (7-915): 2.5e-127: 426: 15.13		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		683833 MAST1_HUMAN (3-947): 3.96e-126: 426: 14.68		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		683838 SIK3_HUMAN (7-915): 2.5e-127: 426: 15.13		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		982637 MAST1_HUMAN (3-947): 3.96e-126: 426: 14.68		1433F_HUMAN (2-242): 2.78e-96: 283: 64.20