HitPredict

Interactor 1: M4K4 (O95819)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: MAP4K4

Interactor 2: PPARG (P37231)
Peroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclear receptor subfamily 1 group C member 3)
Gene: PPARG

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	20195357
Identification Methods	display technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1239 Hs			1 505
+	Hs
		369994 MINK1_HUMAN (1-1239): 0: 1120: 59.29		ESR1_HUMAN (1-501): 9.09e-112: 345: 19.28
+	Hs
		1233527 MINK1_HUMAN (1-1239): 0: 1120: 59.29		ESR2_HUMAN (23-502): 1.79e-98: 308: 18.70
+	Hs
		740515 AAPK1_HUMAN (8-555): 9.95e-123: 392: 16.85		PPARG_HUMAN (1-505): 2.47e-165: 479: 100.00
+	Hs
		1150622 MRCKG_HUMAN (13-974): 7.6e-138: 459: 17.29		ESR2_HUMAN (23-502): 1.79e-98: 308: 18.70
+	Hs
		369024 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		ESR1_HUMAN (1-501): 9.09e-112: 345: 19.28
+	Hs
		148263 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		ESR1_HUMAN (1-501): 9.09e-112: 345: 19.28
+	Hs
		369888 MARK2_HUMAN (8-669): 2.09e-122: 399: 14.10		ESR1_HUMAN (1-501): 9.09e-112: 345: 19.28
+	Hs
		377817 SIK3_HUMAN (7-915): 2.5e-127: 426: 15.13		GCR_HUMAN (18-503): 1.99e-98: 315: 17.85
+	Hs
		369067 AKT2_HUMAN (2-354): 7.38e-124: 393: 21.98		ESR1_HUMAN (1-501): 9.09e-112: 345: 19.28
+	Hs
		369066 AKT1_HUMAN (2-354): 2.35e-122: 388: 20.82		ESR1_HUMAN (1-501): 9.09e-112: 345: 19.28
+	Hs
		647937 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		ESR2_HUMAN (23-502): 1.79e-98: 308: 18.70
+	Hs
		149132 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		ESR2_HUMAN (23-502): 1.79e-98: 308: 18.70
+	Hs
		1183083 MARK2_HUMAN (8-669): 2.09e-122: 399: 14.10		ESR2_HUMAN (23-502): 1.79e-98: 308: 18.70
+	Hs
		487911 AKT1_HUMAN (2-354): 2.35e-122: 388: 20.82		RARA_HUMAN (45-503): 3.89e-102: 316: 25.22
+	Hs
		622765 AKT2_HUMAN (2-354): 7.38e-124: 393: 21.98		COT2_HUMAN (70-501): 3.99e-101: 311: 22.35
+	Hs
		377129 AKT1_HUMAN (2-354): 2.35e-122: 388: 20.82		GCR_HUMAN (18-503): 1.99e-98: 315: 17.85
+	Hs
		611379 AKT1_HUMAN (2-354): 2.35e-122: 388: 20.82		NR4A1_HUMAN (4-503): 3.33e-99: 312: 20.83
+	Hs
		622764 AKT1_HUMAN (2-354): 2.35e-122: 388: 20.82		COT2_HUMAN (70-501): 3.99e-101: 311: 22.35
+	Hs
		611430 STK3_HUMAN (4-499): 3.17e-119: 381: 30.60		NR4A1_HUMAN (4-503): 3.33e-99: 312: 20.83
+	Hs
		1264038 MYO3B_HUMAN (13-330): 5.16e-112: 384: 47.56		ESR2_HUMAN (23-502): 1.79e-98: 308: 18.70