HitPredict

Interactor 1: M4K4 (O95819)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: MAP4K4

Interactor 2: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	34079125, 31871319
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1239 Hs			1 196
+	Hs
		324783 M4K4_HUMAN (1-1239): 0: 1227: 100.00		RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10
+	Hs
		324732 M4K4_HUMAN (1-1239): 0: 1227: 100.00		RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57
+	Hs
		324789 M4K4_HUMAN (1-1239): 0: 1227: 100.00		RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53
+	Hs
		324768 M4K4_HUMAN (1-1239): 0: 1227: 100.00		RAC3_HUMAN (1-179): 1.15e-74: 224: 57.54
+	Hs
		120264 M4K4_HUMAN (1-1239): 0: 1227: 100.00		RHOD_HUMAN (7-182): 3.37e-66: 203: 53.98
+	Hs
		925434 MINK1_HUMAN (1-1239): 0: 1120: 59.29		RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10
+	Mm
		925783 TNIK_MOUSE (1-1239): 0: 1120: 62.43		RAC1_MOUSE (1-196): 2.37e-79: 236: 55.10
+	Hs
		915830 MINK1_HUMAN (1-1239): 0: 1120: 59.29		RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00
+	Hs
		545493 MINK1_HUMAN (1-1239): 0: 1120: 59.29		RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57
+	Hs
		892483 MINK1_HUMAN (1-1239): 0: 1120: 59.29		RAC3_HUMAN (1-179): 1.15e-74: 224: 57.54
+	Hs
		916061 TNIK_HUMAN (1-1239): 0: 1101: 60.56		RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00
+	Hs
		564611 MINK1_HUMAN (1-1239): 0: 1120: 59.29		RHOQ_HUMAN (2-195): 6.71e-68: 207: 51.74
+	Hs
		120535 MINK1_HUMAN (1-1239): 0: 1120: 59.29		RHOD_HUMAN (7-182): 3.37e-66: 203: 53.98
+	Hs
		925356 MRCKG_HUMAN (13-974): 7.6e-138: 459: 17.29		RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10
+	Hs
		894128 MRCKG_HUMAN (13-974): 7.6e-138: 459: 17.29		CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49
+	Dm
		776947 GEK_DROME (15-983): 3.23e-136: 456: 13.20		CDC42_DROME (1-196): 3.02e-74: 223: 49.49
+	Hs
		564571 MRCKG_HUMAN (13-974): 7.6e-138: 459: 17.29		RHOQ_HUMAN (2-195): 6.71e-68: 207: 51.74
+	Hs
		545213 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57
+	Hs
		436165 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		RHOC_HUMAN (1-196): 8.84e-76: 227: 83.16
+	Hs
		120307 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		RHOD_HUMAN (7-182): 3.37e-66: 203: 53.98