HitPredict

Interactor 1: M4K4 (O95819)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: MAP4K4

Interactor 2: AMOT (Q4VCS5)
Angiomotin
Gene: AMOT

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1239 Hs			1 1084
+	Mm
		949320 TNIK_MOUSE (1-1239): 0: 1120: 62.43		FKB15_MOUSE (247-1080): 4.45e-38: 157: 13.19
+	Hs
		1132678 TNIK_HUMAN (1-1239): 0: 1101: 60.56		FKB15_HUMAN (184-1080): 4.84e-41: 166: 14.92
+	Mm
		823531 TNIK_MOUSE (1-1239): 0: 1120: 62.43		CTRO_MOUSE (533-855): 2.5e-11: 70.3: 11.15
+	Hs
		1356429 TNIK_HUMAN (1-1239): 0: 1101: 60.56		PCLO_HUMAN (834-1051): 2.15e-09: 64.2: 18.30
+	Hs
		1051507 TNIK_HUMAN (1-1239): 0: 1101: 60.56		DCTN1_HUMAN (510-863): 3.81e-09: 63.3: 14.85
+	Hs
		847120 SIK3_HUMAN (7-915): 2.5e-127: 426: 15.13		SMCA4_HUMAN (46-592): 7.62e-32: 137: 12.59
+	Hs
		148554 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		SMCA4_HUMAN (46-592): 7.62e-32: 137: 12.59
+	Hs
		847056 MARK4_HUMAN (16-693): 2.51e-123: 400: 18.06		SMCA4_HUMAN (46-592): 7.62e-32: 137: 12.59
+	Hs
		148466 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		MYH11_HUMAN (287-805): 2.02e-17: 90.4: 10.08
+	Hs
		148460 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		MYH9_HUMAN (51-655): 1.51e-14: 81.1: 9.31
+	Hs
		724967 MARK4_HUMAN (16-693): 2.51e-123: 400: 18.06		MYH9_HUMAN (51-655): 1.51e-14: 81.1: 9.31
+	Hs
		148126 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		CTRO_HUMAN (533-815): 3.66e-12: 73.4: 12.37
+	Hs
		148461 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		MYH10_HUMAN (479-879): 3.84e-12: 73: 12.04
+	Hs
		725223 MARK4_HUMAN (16-693): 2.51e-123: 400: 18.06		MYH10_HUMAN (479-879): 3.84e-12: 73: 12.04
+	Hs
		149481 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		PCLO_HUMAN (834-1051): 2.15e-09: 64.2: 18.30
+	Hs
		681696 AKT1_HUMAN (2-354): 2.35e-122: 388: 20.82		MYH9_HUMAN (51-655): 1.51e-14: 81.1: 9.31
+	Hs
		148801 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		DCTN1_HUMAN (510-863): 3.81e-09: 63.3: 14.85
+	Hs
		1051339 MARK2_HUMAN (8-669): 2.09e-122: 399: 14.10		DCTN1_HUMAN (510-863): 3.81e-09: 63.3: 14.85
+	Hs
		522546 STK3_HUMAN (4-499): 3.17e-119: 381: 30.60		MYH1_HUMAN (381-687): 4.64e-14: 79.5: 13.69
+	Hs
		681840 AKT1_HUMAN (2-354): 2.35e-122: 388: 20.82		DCTN1_HUMAN (510-863): 3.81e-09: 63.3: 14.85