HitPredict

Interactor 1: M4K4 (O95819)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: MAP4K4

Interactor 2: H2B2F (Q5QNW6)
Histone H2B type 2-F (H2B-clustered histone 18)
Gene: H2BC18

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.50	0.407

Property	Details
Experiments	35271311
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1239 Hs			1 126
+	Hs
		324778 M4K4_HUMAN (1-1239): 0: 1227: 100.00		H2B1C_HUMAN (1-126): 6.35e-55: 169: 98.41
+	Hs
		324812 M4K4_HUMAN (1-1239): 0: 1227: 100.00		H2B2E_HUMAN (1-126): 3.79e-55: 169: 97.62
+	Hs
		324766 M4K4_HUMAN (1-1239): 0: 1227: 100.00		H2B1D_HUMAN (1-126): 1.76e-54: 168: 97.62
+	Hs
		324840 M4K4_HUMAN (1-1239): 0: 1227: 100.00		H2B3B_HUMAN (1-126): 8.14e-53: 164: 95.24
+	Hs
		148194 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		H2B1K_HUMAN (1-126): 7.91e-55: 169: 97.62
+	Hs
		148290 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		H2B1J_HUMAN (1-126): 4.14e-55: 169: 96.83
+	Hs
		148588 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		H2BFS_HUMAN (1-126): 7.4e-55: 169: 96.03
+	Hs
		149215 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		H2B1L_HUMAN (1-126): 1.29e-53: 166: 96.83
+	Hs
		149042 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		H2B3B_HUMAN (1-126): 8.14e-53: 164: 95.24
+	Hs
		617927 AKT2_HUMAN (2-354): 7.38e-124: 393: 21.98		H2B1O_HUMAN (1-126): 1.56e-55: 170: 98.41
+	Hs
		420807 AKT2_HUMAN (2-354): 7.38e-124: 393: 21.98		H2B1J_HUMAN (1-126): 4.14e-55: 169: 96.83
+	Hs
		682181 AKT2_HUMAN (2-354): 7.38e-124: 393: 21.98		H2B2E_HUMAN (1-126): 3.79e-55: 169: 97.62
+	Hs
		682137 AKT2_HUMAN (2-354): 7.38e-124: 393: 21.98		H2B1B_HUMAN (1-126): 9.02e-55: 168: 96.03
+	Mm
		682111 AKT1_MOUSE (2-354): 1.36e-122: 389: 20.82		H2B2B_MOUSE (1-126): 7.66e-56: 171: 100.00
+	Hs
		617926 AKT1_HUMAN (2-354): 2.35e-122: 388: 20.82		H2B1O_HUMAN (1-126): 1.56e-55: 170: 98.41
+	Mm
		682113 AKT1_MOUSE (2-354): 1.36e-122: 389: 20.82		H2B1C_MOUSE (1-126): 6.35e-55: 169: 98.41
+	Hs
		149147 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		H2B1A_HUMAN (1-126): 3.1e-48: 152: 84.25
+	Hs
		420806 AKT1_HUMAN (2-354): 2.35e-122: 388: 20.82		H2B1J_HUMAN (1-126): 4.14e-55: 169: 96.83
+	Hs
		682194 AKT2_HUMAN (2-354): 7.38e-124: 393: 21.98		H2B3B_HUMAN (1-126): 8.14e-53: 164: 95.24
+	Hs
		1150514 BRSK1_HUMAN (22-753): 9.31e-120: 391: 17.08		H2B2C_HUMAN (1-96): 1.25e-44: 145: 88.54