HitPredict

Interactor 1: M4K4 (O95819)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: MAP4K4

Interactor 2: MOB1B (Q7L9L4)
MOB kinase activator 1B (Mob1 homolog 1A) (Mob1A) (Mob1B) (Mps one binder kinase activator-like 1A)
Gene: MOB1B

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	37536630, 24255178
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1239 Hs			1 216
+	Hs
		324883 M4K4_HUMAN (1-1239): 0: 1227: 100.00		MOB1A_HUMAN (1-216): 5.45e-119: 338: 95.83
+	Hs
		324837 M4K4_HUMAN (1-1239): 0: 1227: 100.00		MOB3B_HUMAN (5-212): 3.49e-108: 311: 53.59
+	Hs
		324861 M4K4_HUMAN (1-1239): 0: 1227: 100.00		MOB3A_HUMAN (5-212): 3.88e-106: 306: 53.11
+	Hs
		324831 M4K4_HUMAN (1-1239): 0: 1227: 100.00		MOB3C_HUMAN (5-212): 1.7e-105: 304: 48.80
+	Hs
		324908 M4K4_HUMAN (1-1239): 0: 1227: 100.00		PHOCN_HUMAN (6-201): 3.76e-67: 207: 19.60
+	Hs
		1198329 MINK1_HUMAN (1-1239): 0: 1120: 59.29		MOB3B_HUMAN (5-212): 3.49e-108: 311: 53.59
+	Hs
		1174260 MINK1_HUMAN (1-1239): 0: 1120: 59.29		MOB3C_HUMAN (5-212): 1.7e-105: 304: 48.80
+	Hs
		1233571 MINK1_HUMAN (1-1239): 0: 1120: 59.29		PHOCN_HUMAN (6-201): 3.76e-67: 207: 19.60
+	Mm
		949324 TNIK_MOUSE (1-1239): 0: 1120: 62.43		PHOCN_MOUSE (6-201): 3.76e-67: 207: 19.60
+	Hs
		1356420 TNIK_HUMAN (1-1239): 0: 1101: 60.56		PHOCN_HUMAN (6-201): 3.76e-67: 207: 19.60
+	Hs
		1027391 STK3_HUMAN (4-499): 3.17e-119: 381: 30.60		MOB1B_HUMAN (1-216): 4.62e-119: 338: 100.00
+	Hs
		1027437 STK3_HUMAN (4-499): 3.17e-119: 381: 30.60		MOB1A_HUMAN (1-216): 5.45e-119: 338: 95.83
+	Hs
		1023070 STK4_HUMAN (4-517): 8.55e-119: 379: 31.92		MOB1B_HUMAN (1-216): 4.62e-119: 338: 100.00
+	Hs
		1023117 STK4_HUMAN (4-517): 8.55e-119: 379: 31.92		MOB1A_HUMAN (1-216): 5.45e-119: 338: 95.83
+	Hs
		1027394 STK3_HUMAN (4-499): 3.17e-119: 381: 30.60		MOB3B_HUMAN (5-212): 3.49e-108: 311: 53.59
+	Dm
		1178592 Q7KV89_DROME (3-813): 4.51e-117: 393: 40.32		MOB4_DROME (6-201): 8.31e-70: 214: 20.10
+	Hs
		1027459 STK3_HUMAN (4-499): 3.17e-119: 381: 30.60		PHOCN_HUMAN (6-201): 3.76e-67: 207: 19.60
+	Hs
		1023145 STK4_HUMAN (4-517): 8.55e-119: 379: 31.92		PHOCN_HUMAN (6-201): 3.76e-67: 207: 19.60
+	Dm
		1178607 Q9VEN3_DROME (20-340): 7.49e-112: 366: 42.72		MOB4_DROME (6-201): 8.31e-70: 214: 20.10
+	Hs
		131625 STK25_HUMAN (14-452): 5.34e-114: 364: 34.99		PHOCN_HUMAN (6-201): 3.76e-67: 207: 19.60