HitPredict

Interactor 1: M4K4 (O95819)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: MAP4K4

Interactor 2: RHOF (Q9HBH0)
Rho-related GTP-binding protein RhoF (Rho family GTPase Rif) (Rho in filopodia)
Gene: RHOF

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1239 Hs			1 211
+	Hs
		120264 M4K4_HUMAN (1-1239): 0: 1227: 100.00		RHOD_HUMAN (5-198): 4.14e-90: 265: 52.06
+	Hs
		324783 M4K4_HUMAN (1-1239): 0: 1227: 100.00		RAC1_HUMAN (20-211): 9.06e-84: 248: 49.48
+	Hs
		324732 M4K4_HUMAN (1-1239): 0: 1227: 100.00		RAC2_HUMAN (20-211): 2.82e-79: 237: 49.48
+	Hs
		324789 M4K4_HUMAN (1-1239): 0: 1227: 100.00		RHOG_HUMAN (19-211): 4.47e-79: 236: 46.11
+	Hs
		324768 M4K4_HUMAN (1-1239): 0: 1227: 100.00		RAC3_HUMAN (20-193): 1.33e-77: 232: 50.58
+	Hs
		324776 M4K4_HUMAN (1-1239): 0: 1227: 100.00		RHOB_HUMAN (21-200): 2.02e-58: 184: 48.89
+	Hs
		120535 MINK1_HUMAN (1-1239): 0: 1120: 59.29		RHOD_HUMAN (5-198): 4.14e-90: 265: 52.06
+	Hs
		925434 MINK1_HUMAN (1-1239): 0: 1120: 59.29		RAC1_HUMAN (20-211): 9.06e-84: 248: 49.48
+	Mm
		925783 TNIK_MOUSE (1-1239): 0: 1120: 62.43		RAC1_MOUSE (20-211): 9.06e-84: 248: 49.48
+	Hs
		1233546 MINK1_HUMAN (1-1239): 0: 1120: 59.29		RHOF_HUMAN (1-211): 5.13e-79: 237: 100.00
+	Hs
		545493 MINK1_HUMAN (1-1239): 0: 1120: 59.29		RAC2_HUMAN (20-211): 2.82e-79: 237: 49.48
+	Hs
		564611 MINK1_HUMAN (1-1239): 0: 1120: 59.29		RHOQ_HUMAN (14-209): 4.28e-77: 232: 46.43
+	Hs
		892483 MINK1_HUMAN (1-1239): 0: 1120: 59.29		RAC3_HUMAN (20-193): 1.33e-77: 232: 50.58
+	Hs
		915830 MINK1_HUMAN (1-1239): 0: 1120: 59.29		RHOB_HUMAN (21-200): 2.02e-58: 184: 48.89
+	Hs
		916061 TNIK_HUMAN (1-1239): 0: 1101: 60.56		RHOB_HUMAN (21-200): 2.02e-58: 184: 48.89
+	Hs
		925356 MRCKG_HUMAN (13-974): 7.6e-138: 459: 17.29		RAC1_HUMAN (20-211): 9.06e-84: 248: 49.48
+	Hs
		564571 MRCKG_HUMAN (13-974): 7.6e-138: 459: 17.29		RHOQ_HUMAN (14-209): 4.28e-77: 232: 46.43
+	Hs
		894128 MRCKG_HUMAN (13-974): 7.6e-138: 459: 17.29		CDC42_HUMAN (19-211): 1.19e-77: 232: 44.04
+	Dm
		776947 GEK_DROME (15-983): 3.23e-136: 456: 13.20		CDC42_DROME (19-211): 5.08e-77: 231: 44.04
+	Hs
		120307 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		RHOD_HUMAN (5-198): 4.14e-90: 265: 52.06