HitPredict

Interactor 1: M4K4 (O95819)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: MAP4K4

Interactor 2: CT2NL (Q9P2B4)
CTTNBP2 N-terminal-like protein
Gene: CTTNBP2NL

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.639

Property	Details
Experiments	32640226, 35271311
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1239 Hs			1 639
+	Hs
		324853 M4K4_HUMAN (1-1239): 0: 1227: 100.00		CTTB2_HUMAN (1-639): 1.57e-58: 215: 38.46
+	Hs
		1233557 MINK1_HUMAN (1-1239): 0: 1120: 59.29		CT2NL_HUMAN (1-639): 5.46e-54: 197: 100.00
+	Hs
		1264914 TNIK_HUMAN (1-1239): 0: 1101: 60.56		CTTB2_HUMAN (1-639): 1.57e-58: 215: 38.46
+	Mm
		82720 TNIK_MOUSE (1-1239): 0: 1120: 62.43		CTTB2_MOUSE (1-639): 5.33e-48: 184: 36.28
+	Hs
		1350214 TNIK_HUMAN (1-1239): 0: 1101: 60.56		CT2NL_HUMAN (1-639): 5.46e-54: 197: 100.00
+	Hs
		547137 MINK1_HUMAN (1-1239): 0: 1120: 59.29		EZRI_HUMAN (122-289): 3.32e-10: 65: 18.82
+	Hs
		547270 TNIK_HUMAN (1-1239): 0: 1101: 60.56		EZRI_HUMAN (122-289): 3.32e-10: 65: 18.82
+	Hs
		149008 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		LUZP1_HUMAN (4-486): 5.63e-35: 144: 15.93
+	Hs
		546938 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		EZRI_HUMAN (122-289): 3.32e-10: 65: 18.82
+	Hs
		148841 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		PLEC_HUMAN (110-303): 6.93e-11: 68.1: 19.49
+	Hs
		148355 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		EZRI_HUMAN (122-289): 3.32e-10: 65: 18.82
+	Hs
		148460 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		MYH9_HUMAN (1-396): 1.07e-09: 64: 12.53
+	Hs
		148466 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		MYH11_HUMAN (1-353): 4.76e-09: 62.1: 11.30
+	Hs
		148461 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		MYH10_HUMAN (1-321): 7.77e-09: 61.3: 15.06
+	Hs
		547111 MARK2_HUMAN (8-669): 2.09e-122: 399: 14.10		EZRI_HUMAN (122-289): 3.32e-10: 65: 18.82
+	Hs
		724967 MARK4_HUMAN (16-693): 2.51e-123: 400: 18.06		MYH9_HUMAN (1-396): 1.07e-09: 64: 12.53
+	Hs
		725223 MARK4_HUMAN (16-693): 2.51e-123: 400: 18.06		MYH10_HUMAN (1-321): 7.77e-09: 61.3: 15.06
+	Hs
		681696 AKT1_HUMAN (2-354): 2.35e-122: 388: 20.82		MYH9_HUMAN (1-396): 1.07e-09: 64: 12.53
+	Hs
		522610 STK3_HUMAN (4-499): 3.17e-119: 381: 30.60		MYH7_HUMAN (3-329): 9.35e-10: 64: 12.39
+	Hs
		522546 STK3_HUMAN (4-499): 3.17e-119: 381: 30.60		MYH1_HUMAN (3-367): 2.27e-09: 62.8: 12.43