HitPredict

Interactor 1: AIFM1 (O95831)
Apoptosis-inducing factor 1, mitochondrial (EC 1.6.99.-) (Programmed cell death protein 8)
Gene: AIFM1

Interactor 2: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	33731348, 21182205
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0071392 - cellular response to estradiol stimulus
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 613 Hs			1 595
+	Hs
		325040 AIFM1_HUMAN (1-613): 0: 581: 100.00		COT2_HUMAN (113-554): 1.44e-106: 328: 22.70
+	Hs
		369713 TRXR1_HUMAN (152-593): 1.45e-92: 300: 14.93		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		452847 DLDH_HUMAN (108-599): 3.31e-98: 310: 14.59		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		1088488 TRXR1_HUMAN (152-593): 1.45e-92: 300: 14.93		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		487484 TRXR1_HUMAN (152-593): 1.45e-92: 300: 14.93		ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16