HitPredict

Interactor 1: LATS1 (O95835)
Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts)
Gene: LATS1

Interactor 2: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	28068668
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0019901 - protein kinase binding GO:0030331 - nuclear estrogen receptor binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1130 Hs			1 595
+	Hs
		369645 STK38_HUMAN (622-1089): 5.96e-165: 497: 40.17		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		369066 AKT1_HUMAN (595-1081): 5.84e-141: 435: 24.50		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		369067 AKT2_HUMAN (603-1075): 3.93e-140: 433: 25.31		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		368941 KAPCA_HUMAN (661-1058): 6.14e-138: 422: 31.59		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		487788 LATS2_HUMAN (13-1121): 0: 751: 49.61		ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16
+	Hs
		369789 MRCKA_HUMAN (694-1047): 2.92e-66: 248: 39.06		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		370819 MRCKB_HUMAN (695-1047): 8.47e-63: 236: 38.06		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		568575 KAPCA_HUMAN (661-1058): 6.14e-138: 422: 31.59		HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58
+	Hs
		377129 AKT1_HUMAN (595-1081): 5.84e-141: 435: 24.50		GCR_HUMAN (5-557): 4.67e-109: 346: 22.51
+	Hs
		611379 AKT1_HUMAN (595-1081): 5.84e-141: 435: 24.50		NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54
+	Hs
		622764 AKT1_HUMAN (595-1081): 5.84e-141: 435: 24.50		COT2_HUMAN (113-554): 1.44e-106: 328: 22.70
+	Hs
		622765 AKT2_HUMAN (603-1075): 3.93e-140: 433: 25.31		COT2_HUMAN (113-554): 1.44e-106: 328: 22.70
+	Hs
		487911 AKT1_HUMAN (595-1081): 5.84e-141: 435: 24.50		RARA_HUMAN (81-545): 1.35e-102: 320: 22.37
+	Hs
		1270038 MRCKB_HUMAN (695-1047): 8.47e-63: 236: 38.06		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		1150622 MRCKG_HUMAN (694-1047): 3.05e-61: 231: 38.23		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		487170 AKT1_HUMAN (595-1081): 5.84e-141: 435: 24.50		ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16
+	Hs
		659748 MRCKB_HUMAN (695-1047): 8.47e-63: 236: 38.06		RXRB_HUMAN (144-549): 1.9e-111: 345: 27.64
+	Hs
		487504 MRCKA_HUMAN (694-1047): 2.92e-66: 248: 39.06		ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16
+	Hs
		487519 MRCKG_HUMAN (694-1047): 3.05e-61: 231: 38.23		ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16