HitPredict

Interactor 1: LATS1 (O95835)
Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts)
Gene: LATS1

Interactor 2: KAP0 (P10644)
cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue-specific extinguisher 1) (TSE1)
Gene: PRKAR1A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	35941108, 36736316
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~cNMP_binding, Pkinase~RIIa
Common GO terms	GO:0005813 - centrosome GO:0005829 - cytosol
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 1130 Hs			1 381
+	Hs
		498359 LATS2_HUMAN (13-1121): 0: 751: 49.61		KAP0_HUMAN (1-381): 1.4e-139: 404: 100.00
+	Hs
		498221 AKT1_HUMAN (595-1081): 5.84e-141: 435: 24.50		KAP0_HUMAN (1-381): 1.4e-139: 404: 100.00
+	Hs
		498202 KAPCA_HUMAN (661-1058): 6.14e-138: 422: 31.59		KAP0_HUMAN (1-381): 1.4e-139: 404: 100.00
+	Hs
		568558 KAPCA_HUMAN (661-1058): 6.14e-138: 422: 31.59		KAP1_HUMAN (1-381): 1.35e-138: 401: 81.37
+	Mm
		397222 KAPCA_MOUSE (661-1056): 5.3e-133: 409: 31.25		KAP0_MOUSE (1-381): 2.58e-141: 408: 96.85
+	Hs
		498210 KAPCB_HUMAN (661-1055): 5.19e-133: 410: 31.58		KAP0_HUMAN (1-381): 1.4e-139: 404: 100.00
+	Hs
		610685 KAPCB_HUMAN (661-1055): 5.19e-133: 410: 31.58		KAP1_HUMAN (1-381): 1.35e-138: 401: 81.37
+	Hs
		498269 ROCK1_HUMAN (694-1046): 9.23e-66: 245: 39.94		KAP0_HUMAN (1-381): 1.4e-139: 404: 100.00
+	Hs
		568559 KAPCA_HUMAN (661-1058): 6.14e-138: 422: 31.59		KAP3_HUMAN (10-253): 4.9e-21: 95.9: 18.21
+	Hs
		533780 KAPCA_HUMAN (661-1058): 6.14e-138: 422: 31.59		KAP2_HUMAN (233-379): 1.21e-17: 85.5: 26.53
+	Hs
		610686 KAPCB_HUMAN (661-1055): 5.19e-133: 410: 31.58		KAP3_HUMAN (10-253): 4.9e-21: 95.9: 18.21
+	Mm
		397199 KAPCA_MOUSE (661-1056): 5.3e-133: 409: 31.25		KAP3_MOUSE (10-253): 2.54e-21: 96.6: 18.57
+	Hs
		533786 KAPCB_HUMAN (661-1055): 5.19e-133: 410: 31.58		KAP2_HUMAN (233-379): 1.21e-17: 85.5: 26.53