HitPredict

Interactor 1: LATS1 (O95835)
Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts)
Gene: LATS1

Interactor 2: MYH6 (P13533)
Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha)
Gene: MYH6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol GO:0019901 - protein kinase binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1130 Hs			1 1939
+	Hs
		528359 KAPCB_HUMAN (661-1055): 5.19e-133: 410: 31.58		MYH6_HUMAN (1-1939): 0: 1172: 100.00
+	Hs
		568568 KAPCA_HUMAN (661-1058): 6.14e-138: 422: 31.59		MYH10_HUMAN (26-1928): 0: 1015: 40.10
+	Hs
		325936 LATS1_HUMAN (1-1130): 0: 934: 100.00		MYH13_HUMAN (1035-1939): 7.94e-63: 240: 17.02
+	Hs
		325609 LATS1_HUMAN (1-1130): 0: 934: 100.00		MYH7_HUMAN (725-1816): 1.63e-62: 239: 17.14
+	Hs
		325612 LATS1_HUMAN (1-1130): 0: 934: 100.00		MYH8_HUMAN (1014-1939): 3.73e-59: 228: 15.86
+	Hs
		325935 LATS1_HUMAN (1-1130): 0: 934: 100.00		MYH2_HUMAN (1067-1939): 8.69e-56: 217: 15.24
+	Hs
		325789 LATS1_HUMAN (1-1130): 0: 934: 100.00		MYH14_HUMAN (770-1831): 9.44e-54: 211: 17.90
+	Hs
		325608 LATS1_HUMAN (1-1130): 0: 934: 100.00		MYH1_HUMAN (1102-1939): 1.21e-51: 204: 16.43
+	Hs
		325955 LATS1_HUMAN (1-1130): 0: 934: 100.00		MYH4_HUMAN (1264-1939): 3.3e-45: 182: 15.09
+	Hs
		325605 LATS1_HUMAN (1-1130): 0: 934: 100.00		MYH3_HUMAN (730-1405): 7.93e-31: 135: 14.90
+	Hs
		725079 ST38L_HUMAN (627-1089): 2.37e-167: 503: 40.82		MYH9_HUMAN (1074-1939): 5.95e-55: 214: 16.42
+	Hs
		681696 AKT1_HUMAN (595-1081): 5.84e-141: 435: 24.50		MYH9_HUMAN (1074-1939): 5.95e-55: 214: 16.42
+	Hs
		568567 KAPCA_HUMAN (661-1058): 6.14e-138: 422: 31.59		MYH9_HUMAN (1074-1939): 5.95e-55: 214: 16.42
+	Hs
		610795 KAPCB_HUMAN (661-1055): 5.19e-133: 410: 31.58		MYH2_HUMAN (1067-1939): 8.69e-56: 217: 15.24
+	Hs
		522538 KAPCB_HUMAN (661-1055): 5.19e-133: 410: 31.58		MYH1_HUMAN (1102-1939): 1.21e-51: 204: 16.43
+	Hs
		610802 KAPCB_HUMAN (661-1055): 5.19e-133: 410: 31.58		MYH4_HUMAN (1264-1939): 3.3e-45: 182: 15.09
+	Hs
		724810 ROCK1_HUMAN (694-1046): 9.23e-66: 245: 39.94		MYH9_HUMAN (1074-1939): 5.95e-55: 214: 16.42