HitPredict

Interactor 1: LATS1 (O95835)
Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts)
Gene: LATS1

Interactor 2: SAV1 (Q9H4B6)
Protein salvador homolog 1 (45 kDa WW domain protein) (hWW45)
Gene: SAV1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	30266805, 33162394, 17379520
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0030216 - keratinocyte differentiation GO:0035329 - hippo signaling GO:0043065 - positive regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1130 Hs			1 383
+	Hs
		325894 LATS1_HUMAN (1-1130): 0: 934: 100.00		SMUF2_HUMAN (119-381): 4.3e-68: 230: 20.14
+	Hs
		325898 LATS1_HUMAN (1-1130): 0: 934: 100.00		SMUF1_HUMAN (147-381): 2.43e-59: 206: 18.32
+	Hs
		1330812 LATS2_HUMAN (13-1121): 0: 751: 49.61		SAV1_HUMAN (1-383): 9.28e-111: 330: 100.00
+	Hs
		325775 LATS1_HUMAN (1-1130): 0: 934: 100.00		WWC2_HUMAN (190-383): 1.85e-37: 146: 20.29
+	Hs
		325853 LATS1_HUMAN (1-1130): 0: 934: 100.00		ITCH_HUMAN (41-315): 8.61e-36: 141: 19.36
+	Hs
		125071 LATS1_HUMAN (1-1130): 0: 934: 100.00		WWP2_HUMAN (45-319): 1.29e-33: 134: 15.85
+	Hs
		325772 LATS1_HUMAN (1-1130): 0: 934: 100.00		MAGI3_HUMAN (156-274): 1.43e-30: 125: 28.46
+	Hs
		325797 LATS1_HUMAN (1-1130): 0: 934: 100.00		KIBRA_HUMAN (197-355): 2.75e-30: 124: 20.47
+	Hs
		325859 LATS1_HUMAN (1-1130): 0: 934: 100.00		MAGI1_HUMAN (170-306): 1.6e-29: 122: 26.55
+	Hs
		325914 LATS1_HUMAN (1-1130): 0: 934: 100.00		WWOX_HUMAN (198-282): 3.98e-30: 121: 31.87
+	Hs
		325886 LATS1_HUMAN (1-1130): 0: 934: 100.00		WWP1_HUMAN (3-322): 5.63e-29: 120: 15.12
+	Hs
		325937 LATS1_HUMAN (1-1130): 0: 934: 100.00		WWC3_HUMAN (194-265): 4.37e-26: 112: 40.48
+	Hs
		325655 LATS1_HUMAN (1-1130): 0: 934: 100.00		NEDD4_HUMAN (42-307): 3.99e-20: 94.4: 14.84
+	Hs
		1149656 LATS2_HUMAN (13-1121): 0: 751: 49.61		WWC2_HUMAN (190-383): 1.85e-37: 146: 20.29
+	Hs
		1220087 LATS2_HUMAN (13-1121): 0: 751: 49.61		KIBRA_HUMAN (197-355): 2.75e-30: 124: 20.47
+	Hs
		1300675 LATS2_HUMAN (13-1121): 0: 751: 49.61		MAGI1_HUMAN (170-306): 1.6e-29: 122: 26.55
+	Hs
		1344970 LATS2_HUMAN (13-1121): 0: 751: 49.61		WWC3_HUMAN (194-265): 4.37e-26: 112: 40.48
+	Hs
		808286 LATS2_HUMAN (13-1121): 0: 751: 49.61		NEDD4_HUMAN (42-307): 3.99e-20: 94.4: 14.84
+	Hs
		1336122 ST38L_HUMAN (627-1089): 2.37e-167: 503: 40.82		SMUF1_HUMAN (147-381): 2.43e-59: 206: 18.32
+	Hs
		1069657 STK38_HUMAN (622-1089): 5.96e-165: 497: 40.17		SMUF1_HUMAN (147-381): 2.43e-59: 206: 18.32