HitPredict

Interactor 1: DLGP3 (O95886)
Disks large-associated protein 3 (DAP-3) (PSD-95/SAP90-binding protein 3) (SAP90/PSD-95-associated protein 3) (SAPAP3)
Gene: DLGAP3

Interactor 2: SHAN3 (Q9BYB0)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2)
Gene: SHANK3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.791

Property	Details
Experiments	10527873, 21653829
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	GKAP~PDZ_6
Common GO terms	GO:0005886 - plasma membrane GO:0014069 - postsynaptic density
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 979 Hs			1 1731
+	Mm
		1115961 DLGP3_MOUSE (1-979): 0: 1267: 94.49		SHAN3_MOUSE (1-1731): 8.04e-176: 579: 93.71
+	Rn
		102520 G3V7T8_RAT (1-979): 0: 1254: 94.59		SHAN3_RAT (1-1731): 3.07e-172: 569: 92.31
+	Hs
		327248 DLGP3_HUMAN (1-979): 0: 1306: 100.00		SHAN2_HUMAN (7-1728): 1.45e-124: 434: 40.04
+	Hs
		1316300 DLGP2_HUMAN (1-979): 0: 1097: 45.66		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		145954 DLGP1_HUMAN (1-979): 0: 1091: 38.63		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Mm
		1116003 DLGP2_MOUSE (1-979): 0: 1100: 45.35		SHAN3_MOUSE (1-1731): 8.04e-176: 579: 93.71
+	Mm
		1116115 DLGP1_MOUSE (1-979): 0: 1061: 37.35		SHAN3_MOUSE (1-1731): 8.04e-176: 579: 93.71
+	Rn
		956996 DLGP1_RAT (1-979): 0: 1056: 37.35		SHAN3_RAT (1-1731): 3.07e-172: 569: 92.31
+	Hs
		1349917 DLGP2_HUMAN (1-979): 0: 1097: 45.66		SHAN2_HUMAN (7-1728): 1.45e-124: 434: 40.04
+	Hs
		145956 DLGP1_HUMAN (1-979): 0: 1091: 38.63		SHAN2_HUMAN (7-1728): 1.45e-124: 434: 40.04
+	Hs
		1316315 DLGP4_HUMAN (1-979): 0: 897: 35.27		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Mm
		69915 DLGP4_MOUSE (1-979): 0: 911: 35.46		SHAN3_MOUSE (1-1731): 8.04e-176: 579: 93.71
+	Mm
		1194593 DLGP1_MOUSE (1-979): 0: 1061: 37.35		SHAN2_MOUSE (356-1728): 4.66e-97: 348: 35.75
+	Rn
		956997 DLGP1_RAT (1-979): 0: 1056: 37.35		SHAN2_RAT (356-1728): 1.67e-96: 346: 35.84
+	Hs
		1357785 DLGP4_HUMAN (1-979): 0: 897: 35.27		SHAN2_HUMAN (7-1728): 1.45e-124: 434: 40.04
+	Rn
		957003 DLGP2_RAT (1-979): 0: 1104: 45.64		SHAN1_RAT (366-1726): 2.72e-29: 130: 14.04
+	Hs
		145958 DLGP1_HUMAN (1-979): 0: 1091: 38.63		SHAN1_HUMAN (320-1726): 3.34e-22: 107: 13.60
+	Rn
		956998 DLGP1_RAT (1-979): 0: 1056: 37.35		SHAN1_RAT (366-1726): 2.72e-29: 130: 14.04
+	Mm
		88376 DLGP1_MOUSE (1-979): 0: 1061: 37.35		SHAN1_MOUSE (323-1726): 7.25e-25: 115: 13.87