HitPredict

Interactor 1: CBX7 (O95931)
Chromobox protein homolog 7
Gene: CBX7

Interactor 2: BMI1 (P35226)
Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51)
Gene: BMI1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	1.00	0.981

Property	Details
Experiments	27705803, 26186194, 28514442, 24981860, 33961781, 19636380, 21282530, 20543829, 17332741, 20601937
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, tandem affinity purification, molecular sieving
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	CBX7_C~RAWUL
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0031519 - PcG protein complex and 1 others more... GO:0035102 - PRC1 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 251 Hs			1 326
+	Hs
		123193 CBX4_HUMAN (1-242): 2.24e-55: 187: 33.60		BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00
+	Hs
		327831 CBX7_HUMAN (1-251): 1.05e-81: 247: 100.00		PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36
+	Hs
		123194 CBX4_HUMAN (1-242): 2.24e-55: 187: 33.60		PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36
+	Mm
		223225 CBX4_MOUSE (1-242): 9.5e-58: 194: 33.60		PCGF2_MOUSE (1-320): 5.49e-113: 332: 61.06
+	Dr
		1186372 Q804D1_DANRE (1-175): 1.64e-41: 149: 35.75		BMI1B_DANRE (1-322): 4e-124: 360: 77.23
+	Hs
		327845 CBX7_HUMAN (1-251): 1.05e-81: 247: 100.00		PCGF3_HUMAN (4-228): 4.43e-72: 225: 34.03
+	Hs
		327861 CBX7_HUMAN (1-251): 1.05e-81: 247: 100.00		PCGF6_HUMAN (2-235): 2.13e-61: 201: 35.12
+	Hs
		327860 CBX7_HUMAN (1-251): 1.05e-81: 247: 100.00		PCGF1_HUMAN (2-229): 5.96e-62: 199: 36.33
+	Hs
		327851 CBX7_HUMAN (1-251): 1.05e-81: 247: 100.00		PCGF5_HUMAN (1-228): 9.27e-56: 183: 30.44
+	Hs
		327858 CBX7_HUMAN (1-251): 1.05e-81: 247: 100.00		RING2_HUMAN (7-227): 8.37e-50: 170: 16.61
+	Hs
		123257 CBX4_HUMAN (1-242): 2.24e-55: 187: 33.60		PCGF3_HUMAN (4-228): 4.43e-72: 225: 34.03
+	Hs
		123317 CBX4_HUMAN (1-242): 2.24e-55: 187: 33.60		PCGF6_HUMAN (2-235): 2.13e-61: 201: 35.12
+	Hs
		123312 CBX4_HUMAN (1-242): 2.24e-55: 187: 33.60		PCGF1_HUMAN (2-229): 5.96e-62: 199: 36.33
+	Hs
		123273 CBX4_HUMAN (1-242): 2.24e-55: 187: 33.60		PCGF5_HUMAN (1-228): 9.27e-56: 183: 30.44
+	Hs
		123174 CBX4_HUMAN (1-242): 2.24e-55: 187: 33.60		RO52_HUMAN (5-198): 5.75e-52: 180: 18.78
+	Hs
		327842 CBX7_HUMAN (1-251): 1.05e-81: 247: 100.00		RING1_HUMAN (7-115): 2.38e-30: 120: 25.46
+	Mm
		223231 CBX4_MOUSE (1-242): 9.5e-58: 194: 33.60		RING2_MOUSE (7-227): 5.77e-50: 171: 16.61
+	Hs
		123308 CBX4_HUMAN (1-242): 2.24e-55: 187: 33.60		RING2_HUMAN (7-227): 8.37e-50: 170: 16.61
+	Mm
		1164651 Q6TKP2_MOUSE (1-198): 5.13e-41: 150: 32.29		RING2_MOUSE (7-227): 5.77e-50: 171: 16.61
+	Hs
		123243 CBX4_HUMAN (1-242): 2.24e-55: 187: 33.60		RING1_HUMAN (7-115): 2.38e-30: 120: 25.46