HitPredict

Interactor 1: CBX7 (O95931)
Chromobox protein homolog 7
Gene: CBX7

Interactor 2: RING2 (Q99496)
E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3) (Protein DinG) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING finger protein BAP-1) (RING-type E3 ubiquitin transferase RING2)
Gene: RNF2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.986

The method score is based on:

Property Details
Experiments 24457600, 27705803, 20696397, 19791798, 26186194, 28514442, 24981860, 33961781, 18927235, 19636380, 21282530, 23523425
Identification Methods affinity chromatography technology, x-ray crystallography, pull down, protein complementation assay, nuclear magnetic resonance, lambda repressor two hybrid, ion exchange chromatography, bimolecular fluorescence complementation, comigration in non denaturing gel electrophoresis, anti tag coimmunoprecipitation and 1 others

more...
Interaction Type physical association, association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains CBX7_C~RAWUL
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0031519 - PcG protein complex
GO:0035102 - PRC1 complex
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Hs

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Last updated: 15 Jul 2024