HitPredict

Interactor 1: BCL10 (O95999)
B-cell lymphoma/leukemia 10 (B-cell CLL/lymphoma 10) (Bcl-10) (CARD-containing molecule enhancing NF-kappa-B) (CARD-like apoptotic protein) (hCLAP) (CED-3/ICH-1 prodomain homologous E10-like regulator) (CIPER) (Cellular homolog of vCARMEN) (cCARMEN) (Cellular-E10) (c-E10) (Mammalian CARD-containing adapter molecule E10) (mE10)
Gene: BCL10

Interactor 2: XIAP (P98170)
E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP)
Gene: XIAP

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	16775419
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CARD~zf-C3HC4_3
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0031398 - positive regulation of protein ubiquitination GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 233 Hs			1 497
+	Hs
		330252 BCL10_HUMAN (1-233): 5.01e-155: 431: 100.00		BIRC2_HUMAN (3-497): 9.73e-82: 267: 23.31
+	Hs
		330251 BCL10_HUMAN (1-233): 5.01e-155: 431: 100.00		BIRC3_HUMAN (150-394): 2.89e-41: 158: 23.94
+	Rn
		1140405 BCL10_RAT (1-233): 1.87e-151: 422: 91.42		Q5XIW4_RAT (150-332): 2.66e-41: 158: 28.83
+	Mm
		1246938 BCL10_MOUSE (1-233): 5.97e-156: 433: 90.99		MIB2_MOUSE (422-496): 9.81e-17: 85.3: 29.33
+	Hs
		330270 BCL10_HUMAN (1-233): 5.01e-155: 431: 100.00		MIB2_HUMAN (437-496): 2e-10: 65.3: 35.00