HitPredict

Interactor 1: PAK4 (O96013)
Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4)
Gene: PAK4

Interactor 2: LYN (P07948)
Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
Gene: LYN

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005794 - Golgi apparatus GO:0005829 - cytosol GO:0005912 - adherens junction and 1 others more... GO:0007165 - signal transduction
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 591 Hs			1 512
+	Hs
		433609 AKT2_HUMAN (261-583): 1.6e-127: 384: 22.94		LYN_HUMAN (1-512): 0: 611: 100.00
+	Hs
		412163 STK4_HUMAN (298-588): 1.44e-122: 372: 35.50		FYN_HUMAN (1-510): 0: 576: 54.12
+	Hs
		522867 KS6A3_HUMAN (265-591): 5.2e-113: 355: 24.27		SRC_HUMAN (1-510): 0: 580: 51.97
+	Hs
		412095 KS6A3_HUMAN (265-591): 5.2e-113: 355: 24.27		FYN_HUMAN (1-510): 0: 576: 54.12
+	Hs
		846470 KCC1A_HUMAN (309-591): 1.33e-127: 380: 26.99		BLK_HUMAN (1-512): 0: 544: 60.00
+	Hs
		412205 KS6A1_HUMAN (275-583): 1.39e-109: 346: 24.39		FYN_HUMAN (1-510): 0: 576: 54.12
+	Hs
		337455 STK4_HUMAN (298-588): 1.44e-122: 372: 35.50		ABL1_HUMAN (32-509): 9.04e-172: 516: 37.88
+	Hs
		789116 KS6A1_HUMAN (275-583): 1.39e-109: 346: 24.39		FRK_HUMAN (32-506): 0: 528: 48.47
+	Hs
		433739 PAK1_HUMAN (3-210): 7.55e-29: 122: 19.62		LYN_HUMAN (1-512): 0: 611: 100.00
+	Hs
		412388 PAK5_HUMAN (1-323): 8.93e-40: 156: 27.68		FYN_HUMAN (1-510): 0: 576: 54.12
+	Hs
		433740 PAK2_HUMAN (8-161): 8.45e-26: 113: 16.67		LYN_HUMAN (1-512): 0: 611: 100.00
+	Hs
		442822 PAK2_HUMAN (8-161): 8.45e-26: 113: 16.67		HCK_HUMAN (1-512): 0: 595: 70.70
+	Hs
		411702 PAK2_HUMAN (8-161): 8.45e-26: 113: 16.67		LCK_HUMAN (1-512): 0: 582: 63.62
+	Hs
		522955 PAK2_HUMAN (8-161): 8.45e-26: 113: 16.67		SRC_HUMAN (1-510): 0: 580: 51.97
+	Hs
		412169 PAK2_HUMAN (8-161): 8.45e-26: 113: 16.67		FYN_HUMAN (1-510): 0: 576: 54.12
+	Hs
		433338 PAK2_HUMAN (8-161): 8.45e-26: 113: 16.67		YES_HUMAN (1-510): 0: 572: 54.26
+	Hs
		337457 PAK2_HUMAN (8-161): 8.45e-26: 113: 16.67		ABL1_HUMAN (32-509): 9.04e-172: 516: 37.88