HitPredict

Interactor 1: PAK4 (O96013)
Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4)
Gene: PAK4

Interactor 2: RAC2 (P15153)
Ras-related C3 botulinum toxin substrate 2 (GX) (Small G protein) (p21-Rac2)
Gene: RAC2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PBD~Ras, Pkinase~Ras
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 591 Hs			1 192
+	Hs
		330967 PAK4_HUMAN (1-591): 0: 586: 100.00		RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19
+	Hs
		330841 PAK4_HUMAN (1-591): 0: 586: 100.00		RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03
+	Hs
		330930 PAK4_HUMAN (1-591): 0: 586: 100.00		RAC3_HUMAN (1-191): 1.72e-78: 234: 89.01
+	Hs
		330976 PAK4_HUMAN (1-591): 0: 586: 100.00		RHOG_HUMAN (1-192): 1.64e-77: 231: 70.83
+	Hs
		330933 PAK4_HUMAN (1-591): 0: 586: 100.00		CDC42_HUMAN (1-192): 4.69e-77: 230: 68.75
+	Hs
		925648 PAK6_HUMAN (1-591): 2.91e-166: 491: 45.72		RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19
+	Hs
		894474 PAK6_HUMAN (1-591): 2.91e-166: 491: 45.72		CDC42_HUMAN (1-192): 4.69e-77: 230: 68.75
+	Dm
		776946 PAKM_DROME (1-589): 9.31e-163: 480: 48.82		CDC42_DROME (1-192): 1.03e-76: 229: 69.27
+	Dm
		776915 PAK_DROME (8-589): 9.88e-153: 457: 34.09		RAC1_DROME (1-192): 7.95e-82: 242: 89.06
+	Dm
		1177643 PAK_DROME (8-589): 9.88e-153: 457: 34.09		Q7JWS8_DROME (2-192): 1.2e-80: 239: 67.54
+	Dm
		819751 PAK_DROME (8-589): 9.88e-153: 457: 34.09		RAC2_DROME (1-192): 2.88e-80: 238: 88.02
+	Dm
		776941 PAK_DROME (8-589): 9.88e-153: 457: 34.09		CDC42_DROME (1-192): 1.03e-76: 229: 69.27
+	Sc
		580325 CLA4_YEAST (1-586): 6.09e-144: 439: 25.83		CDC42_YEAST (1-192): 5.43e-76: 227: 67.19
+	Sc
		580329 STE20_YEAST (11-591): 6.96e-143: 439: 31.62		CDC42_YEAST (1-192): 5.43e-76: 227: 67.19
+	Dm
		776912 Q9VEV1_DROME (2-589): 7.2e-141: 422: 28.74		RAC1_DROME (1-192): 7.95e-82: 242: 89.06
+	Dm
		819750 Q9VEV1_DROME (2-589): 7.2e-141: 422: 28.74		RAC2_DROME (1-192): 2.88e-80: 238: 88.02
+	Dm
		776940 Q9VEV1_DROME (2-589): 7.2e-141: 422: 28.74		CDC42_DROME (1-192): 1.03e-76: 229: 69.27
+	Sc
		580338 SKM1_YEAST (1-586): 4.32e-139: 420: 25.82		CDC42_YEAST (1-192): 5.43e-76: 227: 67.19
+	Hs
		564425 AKT2_HUMAN (261-583): 1.6e-127: 384: 22.94		RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03
+	Ce
		975572 PK1_CAEEL (2-589): 1.24e-122: 375: 31.38		RAC1_CAEEL (1-192): 6e-83: 245: 79.69