HitPredict

Interactor 1: PAK4 (O96013)
Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4)
Gene: PAK4

Interactor 2: RHOQ (P17081)
Rho-related GTP-binding protein RhoQ (Ras-like protein TC10) (Ras-like protein family member 7A)
Gene: RHOQ

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PBD~Ras, Pkinase~Ras
Common GO terms	GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 591 Hs			1 205
+	Hs
		331085 PAK4_HUMAN (1-591): 0: 586: 100.00		RHOJ_HUMAN (9-204): 1.17e-108: 311: 79.59
+	Hs
		330976 PAK4_HUMAN (1-591): 0: 586: 100.00		RHOG_HUMAN (9-199): 2.46e-81: 241: 54.97
+	Hs
		330967 PAK4_HUMAN (1-591): 0: 586: 100.00		RAC1_HUMAN (10-195): 4.15e-80: 238: 63.98
+	Hs
		330933 PAK4_HUMAN (1-591): 0: 586: 100.00		CDC42_HUMAN (9-193): 1.09e-78: 235: 67.57
+	Hs
		330835 PAK4_HUMAN (1-591): 0: 586: 100.00		RAC2_HUMAN (10-196): 1.67e-76: 229: 62.03
+	Hs
		330930 PAK4_HUMAN (1-591): 0: 586: 100.00		RAC3_HUMAN (10-183): 9.1e-76: 227: 66.67
+	Hs
		330955 PAK4_HUMAN (1-591): 0: 586: 100.00		RHOB_HUMAN (1-204): 1.77e-75: 227: 49.51
+	Hs
		1330933 PAK6_HUMAN (1-591): 2.91e-166: 491: 45.72		RHOJ_HUMAN (9-204): 1.17e-108: 311: 79.59
+	Hs
		925648 PAK6_HUMAN (1-591): 2.91e-166: 491: 45.72		RAC1_HUMAN (10-195): 4.15e-80: 238: 63.98
+	Hs
		894474 PAK6_HUMAN (1-591): 2.91e-166: 491: 45.72		CDC42_HUMAN (9-193): 1.09e-78: 235: 67.57
+	Dm
		776946 PAKM_DROME (1-589): 9.31e-163: 480: 48.82		CDC42_DROME (9-193): 1.9e-74: 224: 69.19
+	Sc
		580325 CLA4_YEAST (1-586): 6.09e-144: 439: 25.83		CDC42_YEAST (10-185): 5.8e-85: 251: 66.48
+	Sc
		580329 STE20_YEAST (11-591): 6.96e-143: 439: 31.62		CDC42_YEAST (10-185): 5.8e-85: 251: 66.48
+	Dm
		1177643 PAK_DROME (8-589): 9.88e-153: 457: 34.09		Q7JWS8_DROME (1-195): 1.11e-77: 232: 57.44
+	Dm
		776915 PAK_DROME (8-589): 9.88e-153: 457: 34.09		RAC1_DROME (10-195): 1.67e-76: 229: 63.98
+	Dm
		819751 PAK_DROME (8-589): 9.88e-153: 457: 34.09		RAC2_DROME (10-195): 2.01e-76: 229: 63.44
+	Dm
		776941 PAK_DROME (8-589): 9.88e-153: 457: 34.09		CDC42_DROME (9-193): 1.9e-74: 224: 69.19
+	Dm
		776912 Q9VEV1_DROME (2-589): 7.2e-141: 422: 28.74		RAC1_DROME (10-195): 1.67e-76: 229: 63.98
+	Dm
		819750 Q9VEV1_DROME (2-589): 7.2e-141: 422: 28.74		RAC2_DROME (10-195): 2.01e-76: 229: 63.44
+	Dm
		776940 Q9VEV1_DROME (2-589): 7.2e-141: 422: 28.74		CDC42_DROME (9-193): 1.9e-74: 224: 69.19