HitPredict

Interactor 1: PAK4 (O96013)
Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4)
Gene: PAK4

Interactor 2: RAC3 (P60763)
Ras-related C3 botulinum toxin substrate 3 (EC 3.6.5.2) (p21-Rac3)
Gene: RAC3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PBD~Ras, Pkinase~Ras
Common GO terms	GO:0005829 - cytosol GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 591 Hs			1 192
+	Hs
		330967 PAK4_HUMAN (1-591): 0: 586: 100.00		RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71
+	Hs
		330835 PAK4_HUMAN (1-591): 0: 586: 100.00		RAC2_HUMAN (1-192): 6.96e-81: 240: 88.54
+	Hs
		331085 PAK4_HUMAN (1-591): 0: 586: 100.00		RHOJ_HUMAN (2-190): 2.64e-80: 239: 60.32
+	Hs
		330976 PAK4_HUMAN (1-591): 0: 586: 100.00		RHOG_HUMAN (1-192): 2.62e-78: 233: 69.79
+	Hs
		330933 PAK4_HUMAN (1-591): 0: 586: 100.00		CDC42_HUMAN (1-192): 3.66e-77: 230: 68.75
+	Hs
		330841 PAK4_HUMAN (1-591): 0: 586: 100.00		RHOQ_HUMAN (4-189): 1.4e-73: 222: 63.49
+	Hs
		925648 PAK6_HUMAN (1-591): 2.91e-166: 491: 45.72		RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71
+	Hs
		1330933 PAK6_HUMAN (1-591): 2.91e-166: 491: 45.72		RHOJ_HUMAN (2-190): 2.64e-80: 239: 60.32
+	Hs
		894474 PAK6_HUMAN (1-591): 2.91e-166: 491: 45.72		CDC42_HUMAN (1-192): 3.66e-77: 230: 68.75
+	Dm
		776946 PAKM_DROME (1-589): 9.31e-163: 480: 48.82		CDC42_DROME (1-192): 1.22e-76: 229: 68.23
+	Dm
		776915 PAK_DROME (8-589): 9.88e-153: 457: 34.09		RAC1_DROME (1-192): 2.16e-81: 241: 89.06
+	Dm
		1177643 PAK_DROME (8-589): 9.88e-153: 457: 34.09		Q7JWS8_DROME (2-192): 3.86e-81: 240: 67.54
+	Dm
		819751 PAK_DROME (8-589): 9.88e-153: 457: 34.09		RAC2_DROME (1-192): 1.51e-79: 236: 85.94
+	Dm
		776941 PAK_DROME (8-589): 9.88e-153: 457: 34.09		CDC42_DROME (1-192): 1.22e-76: 229: 68.23
+	Sc
		580325 CLA4_YEAST (1-586): 6.09e-144: 439: 25.83		CDC42_YEAST (1-192): 7.09e-76: 227: 68.75
+	Sc
		580329 STE20_YEAST (11-591): 6.96e-143: 439: 31.62		CDC42_YEAST (1-192): 7.09e-76: 227: 68.75
+	Dm
		776912 Q9VEV1_DROME (2-589): 7.2e-141: 422: 28.74		RAC1_DROME (1-192): 2.16e-81: 241: 89.06
+	Dm
		819750 Q9VEV1_DROME (2-589): 7.2e-141: 422: 28.74		RAC2_DROME (1-192): 1.51e-79: 236: 85.94
+	Dm
		776940 Q9VEV1_DROME (2-589): 7.2e-141: 422: 28.74		CDC42_DROME (1-192): 1.22e-76: 229: 68.23
+	Sc
		580338 SKM1_YEAST (1-586): 4.32e-139: 420: 25.82		CDC42_YEAST (1-192): 7.09e-76: 227: 68.75