HitPredict

Interactor 1: PAK4 (O96013)
Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4)
Gene: PAK4

Interactor 2: ARHG2 (Q92974)
Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40)
Gene: ARHGEF2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	29089450, 22653441
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005794 - Golgi apparatus GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0007049 - cell cycle
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 591 Hs			1 986
+	Hs
		167057 PAK4_HUMAN (1-591): 0: 586: 100.00		ARHGB_HUMAN (109-915): 6.47e-88: 311: 21.18
+	Hs
		1273290 PAK5_HUMAN (1-323): 8.93e-40: 156: 27.68		ARHG2_HUMAN (1-986): 0: 736: 100.00
+	Hs
		1026200 PAK1_HUMAN (3-210): 7.55e-29: 122: 19.62		ARHG2_HUMAN (1-986): 0: 736: 100.00
+	Hs
		850719 KS6A3_HUMAN (265-591): 5.2e-113: 355: 24.27		ARHGC_HUMAN (64-975): 7.9e-104: 357: 16.93
+	Hs
		1073489 KS6A1_HUMAN (275-583): 1.39e-109: 346: 24.39		ARHGC_HUMAN (64-975): 7.9e-104: 357: 16.93
+	Hs
		167086 KS6A1_HUMAN (275-583): 1.39e-109: 346: 24.39		ARHGB_HUMAN (109-915): 6.47e-88: 311: 21.18
+	Hs
		167116 PAK5_HUMAN (1-323): 8.93e-40: 156: 27.68		ARHGB_HUMAN (109-915): 6.47e-88: 311: 21.18
+	Hs
		1026167 PAK1_HUMAN (3-210): 7.55e-29: 122: 19.62		ARHG6_HUMAN (22-797): 1.34e-103: 343: 11.48
+	Hs
		1026158 PAK1_HUMAN (3-210): 7.55e-29: 122: 19.62		ARHG7_HUMAN (22-779): 1.98e-100: 335: 11.77
+	Hs
		1026910 PAK2_HUMAN (8-161): 8.45e-26: 113: 16.67		ARHG6_HUMAN (22-797): 1.34e-103: 343: 11.48
+	Hs
		1026904 PAK2_HUMAN (8-161): 8.45e-26: 113: 16.67		ARHG7_HUMAN (22-779): 1.98e-100: 335: 11.77
+	Hs
		277605 PAK3_HUMAN (3-210): 5.28e-25: 111: 19.56		ARHG7_HUMAN (22-779): 1.98e-100: 335: 11.77
+	Hs
		1217590 M4K3_HUMAN (316-574): 1.61e-52: 195: 40.00		ITSN2_HUMAN (222-599): 8.01e-67: 247: 22.90
+	Mm
		292047 PAK1_MOUSE (3-188): 5.13e-28: 120: 19.25		ARHG7_MOUSE (22-851): 9.73e-95: 321: 12.00
+	Mm
		1142068 PAK3_MOUSE (3-210): 5.38e-24: 108: 20.35		ARHG7_MOUSE (22-851): 9.73e-95: 321: 12.00
+	Hs
		81635 PAK2_HUMAN (8-161): 8.45e-26: 113: 16.67		B7Z6G2_HUMAN (91-795): 2.19e-94: 316: 11.75
+	Hs
		277606 PAK3_HUMAN (3-210): 5.28e-25: 111: 19.56		ITSN1_HUMAN (222-600): 5.07e-70: 257: 22.28