HitPredict

Interactor 1: CHK2 (O96017)
Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2)
Gene: CHEK2

Interactor 2: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.94 0.60 0.751

The method score is based on:

Property Details
Experiments 26121674, 18804494, 10724175, 12049740, 28430840, 12438214, 17380128, 17525332
Identification Methods affinity chromatography technology, pull down, enzymatic study, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0006302 - double-strand break repair
GO:0006974 - DNA damage response
and 3 others

more...
Homologous interactions 4

Homologous interactions

Color coding for hit scores

1 543
Hs

1 1863
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024