HitPredict

Interactor 1: CHK2 (O96017)
Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2)
Gene: CHEK2

Interactor 2: ATM (Q13315)
Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T mutated)
Gene: ATM

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.90 0.60 0.737

The method score is based on:

Property Details
Experiments 20010693, 15064416, 10973490, 15790808, 10744722, 10713094
Identification Methods enzymatic study, pull down, in-gel kinase assay
Interaction Type direct interaction, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000077 - DNA damage checkpoint signaling
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
and 12 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 543
Hs

1 3056
+ Hs
+ Xl
+ Sp
+ Sp
+ Hs
+ Mm
+ Hs
+ Sc
+ Sc
+ At
+ Sp
+ Hs
+ Hs
+ Sc
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

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Last updated: 15 Jul 2024