HitPredict

Interactor 1: CHK2 (O96017)
Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2)
Gene: CHEK2

Interactor 2: SRPK1 (Q96SB4)
SRSF protein kinase 1 (EC 2.7.11.1) (SFRS protein kinase 1) (Serine/arginine-rich protein-specific kinase 1) (SR-protein-specific kinase 1)
Gene: SRPK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.53 1.00 0.735

The method score is based on:

Property Details
Experiments 23602568
Identification Methods enzymatic study, protein kinase assay
Interaction Type direct interaction, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains FHA~Pkinase, Pkinase~Pkinase
Common GO terms GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
and 2 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 543
Hs

1 655
+ Hs
+ Hs
+ Hs
+ Sc
+ Hs
+ Hs
+ Hs
+ At
+ Hs
+ At
+ At
+ At
+ Hs
+ At
+ Hs
+ Hs
+ Hs
+ At
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024