HitPredict

Interactor 1: CCNE2 (O96020)
G1/S-specific cyclin-E2
Gene: CCNE2

Interactor 2: CDN1A (P38936)
Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21)
Gene: CDKN1A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	1.00	0.975

Property	Details
Experiments	26186194, 28514442, 9840927, 15232106, 26496610, 30833792, 33961781, 9840943, 23443559, 24358021
Identification Methods	affinity chromatography technology, pull down, two hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, protein array
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	CDI~Cyclin_N
Common GO terms	GO:0000079 - regulation of cyclin-dependent protein serine/threonine kinase activity GO:0000082 - G1/S transition of mitotic cell cycle GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol and 1 others more... GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 404 Hs			1 164
+	Hs
		624557 CCNE1_HUMAN (1-402): 3.2e-126: 372: 47.16		CDN1A_HUMAN (1-164): 1.8e-69: 209: 100.00
+	Hs
		758294 Q8WUE3_HUMAN (1-370): 7.27e-118: 349: 99.19		CDN1A_HUMAN (1-164): 1.8e-69: 209: 100.00
+	Hs
		331632 CCNE2_HUMAN (1-404): 1.13e-129: 380: 100.00		CDN1B_HUMAN (7-156): 2.96e-42: 141: 25.46
+	Hs
		303835 CCNB2_HUMAN (3-359): 1.26e-102: 311: 21.74		CDN1A_HUMAN (1-164): 1.8e-69: 209: 100.00
+	Hs
		538489 CCNB1_HUMAN (2-362): 3.28e-102: 311: 20.92		CDN1A_HUMAN (1-164): 1.8e-69: 209: 100.00
+	Hs
		87258 C9J2U0_HUMAN (16-402): 1.59e-102: 309: 40.77		CDN1A_HUMAN (1-164): 1.8e-69: 209: 100.00
+	Hs
		624561 CCNE1_HUMAN (1-402): 3.2e-126: 372: 47.16		CDN1B_HUMAN (7-156): 2.96e-42: 141: 25.46
+	Mm
		624384 CCNB1_MOUSE (5-362): 4.01e-101: 308: 21.59		CDN1A_MOUSE (1-164): 5.34e-65: 197: 76.83
+	Hs
		331633 CCNE2_HUMAN (1-404): 1.13e-129: 380: 100.00		CDN1C_HUMAN (8-134): 7.02e-34: 123: 27.91
+	Xl
		841954 CCNE1_XENLA (16-404): 2.65e-119: 354: 44.56		Q91646_XENLA (14-161): 6.75e-45: 148: 25.47
+	Xl
		193814 CCNE3_XENLA (12-403): 4.01e-118: 351: 44.50		Q91646_XENLA (14-161): 6.75e-45: 148: 25.47
+	Hs
		758186 CCNA1_HUMAN (16-367): 2.97e-93: 289: 20.11		CDN1A_HUMAN (1-164): 1.8e-69: 209: 100.00
+	Mm
		803843 CCNE1_MOUSE (1-404): 2.73e-120: 356: 45.19		CDN1B_MOUSE (7-156): 1.74e-39: 134: 27.27
+	Xl
		841953 CCNE1_XENLA (16-404): 2.65e-119: 354: 44.56		Q5V9L9_XENLA (14-156): 1.37e-32: 114: 35.17
+	Hs
		303836 CCNB2_HUMAN (3-359): 1.26e-102: 311: 21.74		CDN1B_HUMAN (7-156): 2.96e-42: 141: 25.46
+	Hs
		538492 CCNB1_HUMAN (2-362): 3.28e-102: 311: 20.92		CDN1B_HUMAN (7-156): 2.96e-42: 141: 25.46
+	Hs
		303838 CCNB2_HUMAN (3-359): 1.26e-102: 311: 21.74		CDN1C_HUMAN (8-134): 7.02e-34: 123: 27.91
+	Hs
		538496 CCNB1_HUMAN (2-362): 3.28e-102: 311: 20.92		CDN1C_HUMAN (8-134): 7.02e-34: 123: 27.91
+	Dm
		872342 CCNE_DROME (17-400): 1.69e-97: 307: 35.06		P91668_DROME (10-163): 1.17e-09: 57.2: 19.46
+	Dm
		872348 CCNE_DROME (17-400): 1.69e-97: 307: 35.06		Q7JNL9_DROME (10-163): 1.05e-09: 57.2: 19.46