HitPredict

Interactor 1: CCNE2 (O96020)
G1/S-specific cyclin-E2
Gene: CCNE2

Interactor 2: CDN1C (P49918)
Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57Kip2)
Gene: CDKN1C

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.43	1.00	0.656

Property	Details
Experiments	9840943
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	CDI~Cyclin_N
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 404 Hs			1 316
+	Hs
		331630 CCNE2_HUMAN (1-404): 1.13e-129: 380: 100.00		CDN1A_HUMAN (17-148): 7.59e-31: 115: 29.20
+	Hs
		624557 CCNE1_HUMAN (1-402): 3.2e-126: 372: 47.16		CDN1A_HUMAN (17-148): 7.59e-31: 115: 29.20
+	Hs
		331632 CCNE2_HUMAN (1-404): 1.13e-129: 380: 100.00		CDN1B_HUMAN (9-201): 9.76e-25: 100: 21.76
+	Hs
		624561 CCNE1_HUMAN (1-402): 3.2e-126: 372: 47.16		CDN1B_HUMAN (9-201): 9.76e-25: 100: 21.76
+	Mm
		803843 CCNE1_MOUSE (1-404): 2.73e-120: 356: 45.19		CDN1B_MOUSE (9-201): 1.47e-28: 110: 23.83
+	Xl
		841953 CCNE1_XENLA (16-404): 2.65e-119: 354: 44.56		Q5V9L9_XENLA (26-155): 9.15e-30: 112: 23.08
+	Hs
		758294 Q8WUE3_HUMAN (1-370): 7.27e-118: 349: 99.19		CDN1A_HUMAN (17-148): 7.59e-31: 115: 29.20
+	Hs
		303838 CCNB2_HUMAN (3-359): 1.26e-102: 311: 21.74		CDN1C_HUMAN (1-316): 3.21e-37: 137: 100.00
+	Hs
		538496 CCNB1_HUMAN (2-362): 3.28e-102: 311: 20.92		CDN1C_HUMAN (1-316): 3.21e-37: 137: 100.00
+	Xl
		841954 CCNE1_XENLA (16-404): 2.65e-119: 354: 44.56		Q91646_XENLA (26-155): 1.89e-17: 81.3: 28.46
+	Xl
		193814 CCNE3_XENLA (12-403): 4.01e-118: 351: 44.50		Q91646_XENLA (26-155): 1.89e-17: 81.3: 28.46
+	Mm
		624384 CCNB1_MOUSE (5-362): 4.01e-101: 308: 21.59		CDN1A_MOUSE (16-155): 5.85e-33: 121: 27.78
+	Hs
		303835 CCNB2_HUMAN (3-359): 1.26e-102: 311: 21.74		CDN1A_HUMAN (17-148): 7.59e-31: 115: 29.20
+	Hs
		538489 CCNB1_HUMAN (2-362): 3.28e-102: 311: 20.92		CDN1A_HUMAN (17-148): 7.59e-31: 115: 29.20
+	Hs
		87258 C9J2U0_HUMAN (16-402): 1.59e-102: 309: 40.77		CDN1A_HUMAN (17-148): 7.59e-31: 115: 29.20
+	Hs
		303836 CCNB2_HUMAN (3-359): 1.26e-102: 311: 21.74		CDN1B_HUMAN (9-201): 9.76e-25: 100: 21.76
+	Hs
		538492 CCNB1_HUMAN (2-362): 3.28e-102: 311: 20.92		CDN1B_HUMAN (9-201): 9.76e-25: 100: 21.76
+	Hs
		758186 CCNA1_HUMAN (16-367): 2.97e-93: 289: 20.11		CDN1A_HUMAN (17-148): 7.59e-31: 115: 29.20
+	Hs
		804103 CCNA1_HUMAN (16-367): 2.97e-93: 289: 20.11		CDN1B_HUMAN (9-201): 9.76e-25: 100: 21.76
+	Xl
		1151481 Q6GME9_XENLA (3-358): 5.72e-92: 284: 21.62		Q91646_XENLA (26-155): 1.89e-17: 81.3: 28.46