HitPredict

Interactor 1: CCNE2 (O96020)
G1/S-specific cyclin-E2
Gene: CCNE2

Interactor 2: CDK3 (Q00526)
Cyclin-dependent kinase 3 (EC 2.7.11.22) (Cell division protein kinase 3)
Gene: CDK3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.902

Property	Details
Experiments	26186194, 28514442, 33961781, 9840943
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Cyclin_C~Pkinase, Cyclin_N~Pkinase
Common GO terms	GO:0000082 - G1/S transition of mitotic cell cycle GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 404 Hs			1 305
+	Hs
		331629 CCNE2_HUMAN (1-404): 1.13e-129: 380: 100.00		CDK2_HUMAN (1-292): 1.87e-148: 420: 76.71
+	Hs
		624573 CCNE1_HUMAN (1-402): 3.2e-126: 372: 47.16		CDK3_HUMAN (1-305): 1.8e-151: 427: 100.00
+	Hs
		624539 CCNE1_HUMAN (1-402): 3.2e-126: 372: 47.16		CDK2_HUMAN (1-292): 1.87e-148: 420: 76.71
+	Rn
		70081 B1WC54_RAT (1-404): 7.36e-124: 366: 45.10		Q6P751_RAT (1-292): 2.23e-148: 419: 76.71
+	Hs
		331626 CCNE2_HUMAN (1-404): 1.13e-129: 380: 100.00		CDK1_HUMAN (1-290): 1.16e-137: 392: 65.98
+	Hs
		625523 Q8WUE3_HUMAN (1-370): 7.27e-118: 349: 99.19		CDK2_HUMAN (1-292): 1.87e-148: 420: 76.71
+	Xl
		193809 CCNE3_XENLA (12-403): 4.01e-118: 351: 44.50		CDK2_XENLA (1-294): 1.88e-147: 417: 75.85
+	Hs
		414745 CCNE1_HUMAN (1-402): 3.2e-126: 372: 47.16		CDK1_HUMAN (1-290): 1.16e-137: 392: 65.98
+	Mm
		956330 CCNE1_MOUSE (1-404): 2.73e-120: 356: 45.19		CDK2_MOUSE (1-292): 1.46e-139: 399: 65.88
+	Hs
		624575 CCNE1_HUMAN (1-402): 3.2e-126: 372: 47.16		CDK5_HUMAN (1-292): 8.97e-133: 380: 60.75
+	Mm
		509485 CCNE1_MOUSE (1-404): 2.73e-120: 356: 45.19		CDK1_MOUSE (1-290): 1.15e-136: 390: 66.32
+	Hs
		624564 CCNE1_HUMAN (1-402): 3.2e-126: 372: 47.16		CDK7_HUMAN (3-296): 2.86e-124: 360: 45.64
+	Hs
		303829 CCNB2_HUMAN (3-359): 1.26e-102: 311: 21.74		CDK2_HUMAN (1-292): 1.87e-148: 420: 76.71
+	Hs
		538471 CCNB1_HUMAN (2-362): 3.28e-102: 311: 20.92		CDK2_HUMAN (1-292): 1.87e-148: 420: 76.71
+	Hs
		303821 CCNB2_HUMAN (3-359): 1.26e-102: 311: 21.74		CDK1_HUMAN (1-290): 1.16e-137: 392: 65.98
+	Hs
		414711 CCNB1_HUMAN (2-362): 3.28e-102: 311: 20.92		CDK1_HUMAN (1-290): 1.16e-137: 392: 65.98
+	Gg
		533892 CCNB2_CHICK (10-362): 1.45e-102: 311: 22.22		CDK1_CHICK (1-300): 8.7e-137: 390: 64.12
+	Hs
		303843 CCNB2_HUMAN (3-359): 1.26e-102: 311: 21.74		CDK5_HUMAN (1-292): 8.97e-133: 380: 60.75
+	Hs
		303844 CCNB2_HUMAN (3-359): 1.26e-102: 311: 21.74		CDK17_HUMAN (1-291): 6.26e-124: 365: 53.43
+	Hs
		538497 CCNB1_HUMAN (2-362): 3.28e-102: 311: 20.92		CDK7_HUMAN (3-296): 2.86e-124: 360: 45.64