HitPredict

Interactor 1: CCNE2 (O96020)
G1/S-specific cyclin-E2
Gene: CCNE2

Interactor 2: CDK10 (Q15131)
Cyclin-dependent kinase 10 (EC 2.7.11.22) (Cell division protein kinase 10) (Serine/threonine-protein kinase PISSLRE)
Gene: CDK10

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36736316
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Cyclin_C~Pkinase, Cyclin_N~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 404 Hs			1 360
+	Hs
		331629 CCNE2_HUMAN (1-404): 1.13e-129: 380: 100.00		CDK2_HUMAN (36-331): 1.52e-139: 399: 43.43
+	Hs
		331637 CCNE2_HUMAN (1-404): 1.13e-129: 380: 100.00		CDK3_HUMAN (36-330): 2.43e-137: 394: 43.92
+	Hs
		624539 CCNE1_HUMAN (1-402): 3.2e-126: 372: 47.16		CDK2_HUMAN (36-331): 1.52e-139: 399: 43.43
+	Hs
		624573 CCNE1_HUMAN (1-402): 3.2e-126: 372: 47.16		CDK3_HUMAN (36-330): 2.43e-137: 394: 43.92
+	Rn
		70081 B1WC54_RAT (1-404): 7.36e-124: 366: 45.10		Q6P751_RAT (36-331): 1.79e-139: 399: 43.10
+	Hs
		331626 CCNE2_HUMAN (1-404): 1.13e-129: 380: 100.00		CDK1_HUMAN (36-332): 2.51e-130: 376: 39.47
+	Xl
		193809 CCNE3_XENLA (12-403): 4.01e-118: 351: 44.50		CDK2_XENLA (36-331): 3.59e-139: 398: 43.77
+	Hs
		414745 CCNE1_HUMAN (1-402): 3.2e-126: 372: 47.16		CDK1_HUMAN (36-332): 2.51e-130: 376: 39.47
+	Hs
		625523 Q8WUE3_HUMAN (1-370): 7.27e-118: 349: 99.19		CDK2_HUMAN (36-331): 1.52e-139: 399: 43.43
+	Hs
		624575 CCNE1_HUMAN (1-402): 3.2e-126: 372: 47.16		CDK5_HUMAN (36-329): 9.05e-129: 372: 43.39
+	Mm
		956330 CCNE1_MOUSE (1-404): 2.73e-120: 356: 45.19		CDK2_MOUSE (36-331): 6.35e-131: 379: 37.10
+	Mm
		509485 CCNE1_MOUSE (1-404): 2.73e-120: 356: 45.19		CDK1_MOUSE (36-332): 8.11e-129: 372: 39.80
+	Hs
		303829 CCNB2_HUMAN (3-359): 1.26e-102: 311: 21.74		CDK2_HUMAN (36-331): 1.52e-139: 399: 43.43
+	Hs
		538471 CCNB1_HUMAN (2-362): 3.28e-102: 311: 20.92		CDK2_HUMAN (36-331): 1.52e-139: 399: 43.43
+	Gg
		533892 CCNB2_CHICK (10-362): 1.45e-102: 311: 22.22		CDK1_CHICK (36-335): 7.83e-131: 377: 39.40
+	Hs
		303821 CCNB2_HUMAN (3-359): 1.26e-102: 311: 21.74		CDK1_HUMAN (36-332): 2.51e-130: 376: 39.47
+	Hs
		414711 CCNB1_HUMAN (2-362): 3.28e-102: 311: 20.92		CDK1_HUMAN (36-332): 2.51e-130: 376: 39.47
+	Hs
		303843 CCNB2_HUMAN (3-359): 1.26e-102: 311: 21.74		CDK5_HUMAN (36-329): 9.05e-129: 372: 43.39
+	Hs
		624564 CCNE1_HUMAN (1-402): 3.2e-126: 372: 47.16		CDK7_HUMAN (37-329): 5.56e-77: 242: 42.91
+	Hs
		538497 CCNB1_HUMAN (2-362): 3.28e-102: 311: 20.92		CDK7_HUMAN (37-329): 5.56e-77: 242: 42.91