HitPredict

Interactor 1: NSD2 (O96028)
Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein)
Gene: NSD2

Interactor 2: KI67 (P46013)
Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67)
Gene: MKI67

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31248990
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005730 - nucleolus
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1365 Hs			1 3256
+	Hs
		331812 NSD2_HUMAN (1-1365): 0: 980: 100.00		MDC1_HUMAN (20-1865): 6.71e-101: 366: 9.14
+	Hs
		331745 NSD2_HUMAN (1-1365): 0: 980: 100.00		MAP1B_HUMAN (771-2622): 1.91e-90: 333: 9.59
+	Hs
		801165 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		KI67_HUMAN (1-3256): 0: 1046: 100.00
+	Hs
		801094 KMT2A_HUMAN (1049-1203): 7.37e-42: 171: 32.05		KI67_HUMAN (1-3256): 0: 1046: 100.00
+	Hs
		152608 KMT2D_HUMAN (69-660): 1.16e-09: 65.7: 8.54		KI67_HUMAN (1-3256): 0: 1046: 100.00
+	Hs
		1244240 NSD3_HUMAN (116-1340): 0: 758: 45.19		BD1L1_HUMAN (98-2862): 2.37e-19: 99.1: 9.63
+	Hs
		1056971 SETD2_HUMAN (852-1238): 1.1e-53: 209: 27.74		MDC1_HUMAN (20-1865): 6.71e-101: 366: 9.14
+	Hs
		807738 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		MAP1B_HUMAN (771-2622): 1.91e-90: 333: 9.59
+	Hs
		807879 KMT2B_HUMAN (1049-1203): 1.21e-41: 170: 32.05		MAP1B_HUMAN (771-2622): 1.91e-90: 333: 9.59
+	Hs
		1056940 NSD1_HUMAN (69-658): 1.83e-25: 117: 14.33		MDC1_HUMAN (20-1865): 6.71e-101: 366: 9.14
+	Hs
		820995 EZH1_HUMAN (932-1188): 1.16e-57: 216: 24.07		PRC2A_HUMAN (513-2601): 5.1e-21: 104: 7.93
+	Hs
		1080130 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		BD1L1_HUMAN (98-2862): 2.37e-19: 99.1: 9.63
+	Hs
		1080263 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		MUC4_HUMAN (409-3101): 1.78e-16: 89.4: 12.06
+	Hs
		975287 KMT2A_HUMAN (1049-1203): 7.37e-42: 171: 32.05		BD1L1_HUMAN (98-2862): 2.37e-19: 99.1: 9.63
+	Hs
		1244252 KMT2B_HUMAN (1049-1203): 1.21e-41: 170: 32.05		BD1L1_HUMAN (98-2862): 2.37e-19: 99.1: 9.63
+	Hs
		975294 KMT2A_HUMAN (1049-1203): 7.37e-42: 171: 32.05		TITIN_HUMAN (52-1221): 1.55e-13: 80: 7.85
+	Hs
		152668 KMT2D_HUMAN (69-660): 1.16e-09: 65.7: 8.54		BD1L1_HUMAN (98-2862): 2.37e-19: 99.1: 9.63
+	Dm
		332876 CHDM_DROME (1238-1285): 6.78e-12: 72.7: 42.00		Q9VPR2_DROME (1964-2639): 2.13e-15: 85: 10.04
+	Dm
		332845 CHDM_DROME (1238-1285): 6.78e-12: 72.7: 42.00		Q9VGW4_DROME (2330-3253): 1.16e-11: 73.6: 13.63